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Titolo:
Neuropathological abnormalities of the corpus callosum in schizophrenia: adiffusion tensor imaging study
Autore:
Foong, J; Maier, M; Clark, CA; Barker, GJ; Miller, DH; Ron, MA;
Indirizzi:
Inst Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nst Neurol, London WC1N 3BG, England
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 2, volume: 68, anno: 2000,
pagine: 242 - 244
SICI:
0022-3050(200002)68:2<242:NAOTCC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER;
Keywords:
corpus callosum; diffusion tensor imaging; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Foong, J Inst Neurol, Queen Sq, London WC1N 3BG, England Inst Neurol QueenSq London England WC1N 3BG n WC1N 3BG, England
Citazione:
J. Foong et al., "Neuropathological abnormalities of the corpus callosum in schizophrenia: adiffusion tensor imaging study", J NE NE PSY, 68(2), 2000, pp. 242-244

Abstract

Objectives-Diffusion tensor imaging (DTI), a technique capable of examining water diffusion in different tissues and the organisation of white mattertracts, was used to investigate the neuropathology of the corpus callosum in vivo in patients with schizophrenia. Methods-Diffusion tensor imaging was performed in 20 schizophrenic patients and 25 healthy controls. Two complementary measures, mean diffusivity andfractional anisotropy, which are considered to be sensitive indices of axonal integrity, were obtained from regions of interest in the genu (anterior) and splenium (posterior) of the corpus callosum. Results-Mean diffusivity was significantly increased and fractional anisotropy significantly reduced in the splenium but not the genu of the corpus callosum in the schizophrenic group compared with controls. There were no significant sex differences in the DTI measures for either the schizophrenic or control group. Clinical variables such as age, duration of illness, doseof antipsychotic medication, and schizophrenic symptoms did not predict the DTI changes in the schizophrenic patients. Conclusions-The presence of DTI changes in the splenium but not the genu of the corpus callosum suggests that there may be a focal disruption of commisural connectivity in schizophrenia. However, these findings do not exclude the possibility of abnormalities in other areas of the corpus callosum orother regions of white matter and further research using different methodsof analysis may enable us to clarify this. Diffusion tensor imaging is a valuable tool in investigating the structure of white matter in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:12:09