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Titolo:
Intrathecal release of sICAM-1 into CSF in neuroborreliosis - increased brain-derived fraction
Autore:
Lewczuk, P; Reiber, H; Korenke, GC; Bollensen, E; Dorta-Contreras, AJ;
Indirizzi:
Univ Gottingen, Neurochem Lab, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Lab, D-37075 Gottingen, Germany Univ Gottingen, Dept Pediat Neurol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 rol, D-37075 Gottingen, Germany Hosp Eschwege, Dept Neurol, D-37269 Eschwege, Germany Hosp Eschwege Eschwege Germany D-37269 Neurol, D-37269 Eschwege, Germany Hosp Pediat San Miguel, Immunol Lab, Havana, Cuba Hosp Pediat San Miguel Havana Cuba an Miguel, Immunol Lab, Havana, Cuba
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 103, anno: 2000,
pagine: 93 - 96
SICI:
0165-5728(20000201)103:1<93:IROSIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; IN-VITRO; CEREBROSPINAL-FLUID; DISEASE; ICAM-1; CELLS;
Keywords:
neuroborreliosis; cerebrospinal fluid; adhesion molecules; sICAM-1; blood-CSF barrier dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Lewczuk, P Max Planck Inst Expt Med, Hermann Rein Str 3, D-37075 Gottingen, Germany Max Planck Inst Expt Med Hermann Rein Str 3 Gottingen Germany D-37075
Citazione:
P. Lewczuk et al., "Intrathecal release of sICAM-1 into CSF in neuroborreliosis - increased brain-derived fraction", J NEUROIMM, 103(1), 2000, pp. 93-96

Abstract

In the present study, we report sICAM-1 concentration in the cerebrospinalfluid (CSF) and serum of patients with neuroborreliosis (NB, n = 11), compared to the data from a control group of patients with corresponding blood/CSF barrier dysfunction but without inflammation in the central nervous system (disc prolaps, DP, n = 11). In NE, the sICAM-1 concentration in CSF wasincreased up to six-fold (ranges: 6.6-42.8 ng/ml and 2.2-9.8 ng/ml for NE and DP respectively) with no change in serum sICAM-1. The corresponding sICAM-1 CSF/serum concentration quotients (Q(ICAM)) were in the ranges: 22.5-171.3 x 10(-3), and 8.8-27.8 x 10(-3) for NE and DP respectively. This finding can be explained by increase of the brain-derived fraction of sICAM-1 inNB. In one case we observed increased Q(ICAM) on the 6th day after admission to the hospital (171.3 X 10(-3) at the time of the first lumbar punctureslightly increasing to 143.6 x 10(-3) five days later), followed by normalization, in two remaining repunctured patients we observed decreasing Q(ICAM) with normalizing Q(Alb). (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:35:09