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Titolo:
A novel high-performance Fourier transform ion cyclotron resonance cell for improved biopolymer characterization
Autore:
Bruce, JE; Anderson, GA; Lin, CY; Gorshkov, M; Rockwood, AL; Smith, RD;
Indirizzi:
Battelle Mem Inst, Pacific NW Labs, Macromol Struct & Dynam Grp, Environm & Mol Sci Lab, Richland, WA 99352 USA Battelle Mem Inst Richland WA USA 99352 l Sci Lab, Richland, WA 99352 USA
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 1, volume: 35, anno: 2000,
pagine: 85 - 94
SICI:
1076-5174(200001)35:1<85:ANHFTI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT DETERMINATION; FTICR MASS-SPECTROMETRY; INDIVIDUAL IONS; EXCITATION; TRAP; RESOLUTION; ELECTRODE; REMEASUREMENT; AXIALIZATION; PROTEINS;
Keywords:
ion trap; electric field; quadrupolar; SIMION; frequency shift; biopolymers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, RD Battelle Mem Inst, Pacific NW Labs, Macromol Struct & Dynam Grp,Environm & Mol Sci Lab, POB 999, Richland, WA 99352 USA Battelle Mem Inst POB 999 Richland WA USA 99352 nd, WA 99352 USA
Citazione:
J.E. Bruce et al., "A novel high-performance Fourier transform ion cyclotron resonance cell for improved biopolymer characterization", J MASS SPEC, 35(1), 2000, pp. 85-94

Abstract

A new trapped ion cell design for use with Fourier transform ion cyclotronresonance mass spectrometry is described. The design employs 15 cylindrical ring electrodes to generate trapping potential wells and 32 separately assignable rod electrodes for excitation and detection. The rod electrodes are positioned internal to the ring electrodes and provide excitation fields that are thereby linearized along the magnetic field over the entire trapped ion volume. The new design also affords flexibility in the shaping of thetrapping field using the 15 ring electrodes. Many different trapping well shapes can be generated by applying different voltages to the individual ring electrodes, ranging from quadratic to linearly ramped along the magneticfield axis, to a shape that is nearly flat over the entire trap volume, but rises very steeply near the ends of the trap. This feature should be useful for trapping larger ion populations and extension of the useful range ofion manipulation and dissociation experiments since the number of stages of ion manipulation or dissociation is limited in practice by the initial trapped ion population size. Predicted trapping well shapes for two differentring electrode configurations are presented, and these and several other possible configurations are discussed, as are the predicted excitation fields based on the use of rod electrodes internal to the trapping ring electrodes. Initial results are presented from an implementation of the design using a 3.5 T superconducting magnet. It was found that ions can be successfully trapped and detected with this cell design and that selected ion accumulation ran be performed with the utilization of four rods for quadrupolar excitation. The initial results presented here illustrate the feasibility of this cell design and demonstrate differences in observed performance based upon different trapping well shapes. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 15:38:06