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Titolo:
Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects
Autore:
Damasceno, A; Santos, A; Serrao, P; Caupers, P; Soares-da-Silva, P; Polonia, J;
Indirizzi:
Fac Med Porto, Unidad Farmacol Clin, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 macol Clin, P-4200 Oporto, Portugal Fac Med Porto, Inst Farmacol & Terapeut, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 & Terapeut, P-4200 Oporto, Portugal Univ Eduardo Mondiane, Fac Med, Maputo, Mozambique Univ Eduardo Mondiane Maputo Mozambique ne, Fac Med, Maputo, Mozambique
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 12, volume: 17, anno: 1999,
parte:, 2
pagine: 1995 - 2001
SICI:
0263-6352(199912)17:12<1995:DORDNR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY DOPAMINE; ESSENTIAL-HYPERTENSION; SYSTEM ACTIVITY; DIETARY-SODIUM; EXCRETION; PLASMA; RAT; DIHYDROXYPHENYLALANINE; DERIVATION; KIDNEY;
Keywords:
black subjects; salt resistance; salt sensitivity; renal dopaminergic system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Polonia, J Fac Med Porto, Unidad Farmacol Clin, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 P-4200 Oporto, Portugal
Citazione:
A. Damasceno et al., "Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects", J HYPERTENS, 17(12), 1999, pp. 1995-2001

Abstract

Objective To evaluate the involvement of the renal dopaminergic system in the natriuretic responses to acute saline load in salt-resistant (SR) and salt-sensitive (SS) black normotensive (NT) and hypertensive (HT) subjects. Design and methods We studied the relationship between the urinary excretion of dopa, dopamine (DA) and its metabolite DOPAC and the natriuretic responses to acute volume expansion (2 I NaCl 0.9% over 2 h) in 20 black NT subjects (12 SR and 8 SS) and 19 black HT subjects (10 SS and 9 SR). Subjects received a low salt (LS) diet (40 mmol sodium/day) for 1 week and a high salt (HS) diet (300 mmol sodium/day) for 1 week; the sequence of the dietary regimens was randomized. Comparisons were made between the results before the saline infusion (baseline) and the results 2 h after the infusion. Results In all the groups saline infusion induced significant increases inurinary volume (ml/4 h) of two- to three-fold and in urinary sodium excretion (mmol/4 h h) of three- to ten-fold; these increases were significantly greater during the HS diet than during the LS diet. Saline infusion significantly increased the mean arterial pressure (MAP) by 5 mmHg in HT-SS subjects and by 4-5 mmHg in NT-SS subjects, but the MAP did not changed in the NT-SR and HT-SR groups. Under the LS diet, saline infusion changed the DA excretion (in nmol/4 h) by -49 +/- 89 in HT-SS subjects, by 17 +/- 52 in NT-SRsubjects, by 235 +/- 72 in HT-SR subjects and by 220 +/- 86 in NT-SR subjects (P < 0.05 between SR and SS subjects). The saline infusion-induced changes in DA excretion correlated significantly with the increases in urinary sodium excretion (r = 0.71, P < 0.01) in the NT-SR and NT-SR subjects underthe LS diet, but not in the SR groups on the HS diet nor in the SS groups (HT and NT) on either diet. Saline infusion significantly reduced the DA/dopa ratio in SS (NT and HT) but not SR (NT and HT) subjects, whereas the DA/DOPAC (dihydroxyphenylacetic acid) ratios were similar in all the groups. Conclusions The urinary dopaminergic system may participate in the natriuretic responses to acute sodium load only in SR subjects (NT and HT) and only under LS diets, but not in SR subjects (NT and HT). This strongly suggests that black NT- and HT-SS subjects have an underlying impairment in the activity of the renal dopaminergic system which may be associated with a reduced decarboxylation of dopa into DA. (C) Lippincott Williams & Wilkins.

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Documento generato il 08/07/20 alle ore 07:41:39