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Titolo:
Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage inhypertensive diabetic rats
Autore:
Fabris, B; Candido, R; Armini, L; Fischetti, F; Calci, M; Bardelli, M; Fazio, M; Campanacci, L; Carretta, R;
Indirizzi:
Univ Trieste, Osped Cattinara, Ist Med Clin, I-34149 Trieste, Italy Univ Trieste Trieste Italy I-34149 Ist Med Clin, I-34149 Trieste, Italy
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 12, volume: 17, anno: 1999,
parte:, 2
pagine: 1925 - 1931
SICI:
0263-6352(199912)17:12<1925:COGHAR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIHYPERTENSIVE THERAPY; NEPHROPATHY; MODEL; KIDNEY; GLOMERULOSCLEROSIS; PERINDOPRIL; CLEARANCE; MELLITUS; INJURY;
Keywords:
ACE inhibition; diabetic nephropathy; glomerular hyperfiltration; hypertension; renal hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fabris, B Univ Trieste, Osped Cattinara, Ist Med Clin, Str Fiume 447, I-34149 Trieste, Italy Univ Trieste Str Fiume 447 Trieste Italy I-34149 Trieste, Italy
Citazione:
B. Fabris et al., "Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage inhypertensive diabetic rats", J HYPERTENS, 17(12), 1999, pp. 1925-1931

Abstract

Objective Glomerular hyperfiltration and renal hypertrophy are both considered important in the progression of diabetic nephropathy. The aim of this study was to compare the effects of an equivalent reduction in blood pressure produced by the angiotensin-converting enzyme (ACE) inhibitor spirapril (SPI) and an antihypertensive triple drug combination of hydralazine, reserpine and hydrochlorothiazide (HRH) on kidney function, proteinuria and renal structure in hypertensive diabetic rats. Design and methods Four groups of animals were evaluated in short-term andlong-term studies. In both studies one group served as a non-diabetic hypertensive control (H). The other three groups were rendered diabetic and were allocated to one of the following groups: the first diabetic group received no specific therapy (HD), the second diabetic group was treated with SPI(HD-SPI) and the third diabetic group was treated with HRH (HD-HRH). In each of the two studies the systolic blood pressure (SBP), 24 h urinary totalprotein, glomerular filtration rate (GFR), glomerular area, proximal tubular area and glomerular sclerosis were evaluated. Results The blood pressure reduction was equal in rats receiving either SPI or HRH, The GFR, proteinuria, glomerular area and tubular area were significantly increased in the HD group, both in the short-term and the long-term study. In the HD-SPI group the diabetic hyperfiltration and renal hypertrophy responses were prevented. In the HD-HRH group the GFR and proteinuria were slightly reduced in the later phases of diabetes, while the glomerulararea and tubular area were not affected. Semiquantitative analysis of renal lesions showed that SPI was more effective than HRH in the prevention of the development of glomerulosclerosis. Conclusions The results of this study suggest that the control of early adaptive hyperfiltration and renal hypertrophy by SPI may be relevant in the prevention of glomerulosclerosis. (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:27:18