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Titolo:
Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats
Autore:
Doi, R; Masuyama, T; Yamamoto, K; Doi, Y; Mano, T; Sakata, Y; Ono, K; Kuzuya, T; Hirota, S; Koyama, T; Miwa, T; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med A8, Dept Internal Med & Therapeut, Dept Med 1, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Med 1, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Dept Pathol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Pathol, Suita, Osaka 5650871, Japan Osaka Univ, Genome Informat Res Ctr, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Res Ctr, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 1, volume: 18, anno: 2000,
pagine: 111 - 120
SICI:
0263-6352(200001)18:1<111:DODPOH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESSURE-OVERLOAD HYPERTROPHY; LEFT-VENTRICULAR GEOMETRY; CORONARY-ARTERY DISEASE; DILATED CARDIOMYOPATHY; CARDIAC-HYPERTROPHY; PROGNOSTIC VALUE; DYSFUNCTION; PATTERNS; STIFFNESS; DIAGNOSIS;
Keywords:
hypertension; heart failure; diastole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Masuyama, T Osaka Univ, Grad Sch Med A8, Dept Internal Med & Therapeut, Dept Med 1, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
R. Doi et al., "Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats", J HYPERTENS, 18(1), 2000, pp. 111-120

Abstract

Objective There are two phenotypes of heart failure, systolic failure and isolated diastolic heart failure with preserved left ventricular systolic function. Although isolated diastolic heart failure frequently occurs, thereare only models for diastolic dysfunction unassociated with heart failure and models with overt diastolic heart failure have not been established. Weattempted to develop two different models, i.e. diastolic and systolic failure models, based on hypertension. Materials and methods Dahl salt-sensitive rats were placed on 8% NaCl dietfrom 7 weeks old (7-week starting group) or 8 weeks old (8-week starting group). As an age-matched control, Dahl salt-sensitive rats were consistently placed on normal chow. In these rats, echocardiogram was serially recorded, followed by hemodynamic and histological studies. Results The 7-week starting rats showed a steep elevation in blood pressure and progressive left ventricular hypertrophy, and fell into overt heart failure at approximately 19 weeks. The development of heart failure was not associated with a decrease in left ventricular midwall fractional shortening or an increase in left ventricular end-diastolic dimension as compared with the age-matched control, which mimics the characteristics of clinically observed isolated diastolic heart failure. The 8-week starting rats showed a gradual rise in blood pressure and less progressive left ventricular hypertrophy, and fell into heart failure at approximately 26 weeks with a decrease in mid-wall fractional shortening and an increase in left ventricular end-diastolic dimension. Hemodynamic and histological studies at failing stage revealed comparable elevation of left ventricular end-diastolic pressureand comparable left ventricular fibrosis in both groups,Conclusion These two different models of overt heart failure may be usefulas models of isolated diastolic heart failure and systolic heart failure based on the same hypertensive heart disease, respectively, and may contribute to discrimination of the mechanisms of the development of the two different phenotypes of heart failure. J Hypertens 2000, 18:111-120 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:02:19