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Titolo:
Re-emergence of chikungunya and o'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships
Autore:
Powers, AM; Brault, AC; Tesh, RB; Weaver, SC;
Indirizzi:
Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Pathol, Galveston, TX 77555 USA Univ Texas, Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 , Ctr Trop Dis, Galveston, TX 77555 USA
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 81, anno: 2000,
parte:, 2
pagine: 471 - 479
SICI:
0022-1317(200002)81:<471:ROCAOV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EQUINE ENCEPHALOMYELITIS COMPLEX; ALPHAVIRUSES; NUCLEOTIDE; EASTERN; RNA; CONSERVATION; ENCEPHALITIS; ANTIBODIES; SEQUENCES; STRAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Powers, AM Univ Texas, Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd Galveston TX USA 77555 n, TX 77555 USA
Citazione:
A.M. Powers et al., "Re-emergence of chikungunya and o'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships", J GEN VIROL, 81, 2000, pp. 471-479

Abstract

Chikungunya (CHIK) virus is a member of the genus Alphavirus in the familyTogaviridae, Serologically, it is most closely related to o'nyong-nyong (ONN) virus and is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa and historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa and Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK andONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa and Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa and the second comprising all southern and East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia. Within the eastern Africa and southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographicalgenotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquitovectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with Ae. furcifer and Ae. africanus mosquitoes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:37:47