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Titolo:
Expression pattern of the bcl-2 homologous protein bad in normal skin, psoriasis vulgaris and keratinocytic tumors
Autore:
Tomkova, H; Fujimoto, W; Arata, J;
Indirizzi:
Okayama Univ, Sch Med, Dept Dermatol, Okayama 7008558, Japan Okayama UnivOkayama Japan 7008558 Dept Dermatol, Okayama 7008558, Japan
Titolo Testata:
JOURNAL OF DERMATOLOGICAL SCIENCE
fascicolo: 2, volume: 22, anno: 2000,
pagine: 132 - 137
SICI:
0923-1811(200002)22:2<132:EPOTBH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL CARCINOMA; APOPTOSIS; FAMILY; DEATH; MITOCHONDRIA; CANCERS;
Keywords:
apoptosis; bad; bcl-2 family; skill disease; psoriasis vulgaris; non-melanoma skin cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimoto, W Okayama Univ, Sch Med, Dept Dermatol, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8, Japan
Citazione:
H. Tomkova et al., "Expression pattern of the bcl-2 homologous protein bad in normal skin, psoriasis vulgaris and keratinocytic tumors", J DERMA SCI, 22(2), 2000, pp. 132-137

Abstract

Previous investigations focused on the mechanisms and regulation of apoptotic process have found that bcl-2 and its homologous proteins are central regulators of the mitochondrial phase of apoptosis. Expression of several members of the bcl-2 family has been studied in various tissues including skill under normal as well as disease conditions. In this report, we investigated the expression of bad, the pro-apoptotic member of the BH3 subfamily, in normal and psoriatic epidermis, keratoacanthoma, and basal and squamous cell carcinomas. Normal and psoriatic epidermis showed accentuation of the staining in the lower suprabasal compartment. a weak, predominantly diffuse staining pattern was observed in the upper epidermis of psoriatic plaques. Keratoacanthoma showed strong but diffuse immunostaining for pro-apoptotic bad, however we found only weak bad expression in squamous cell carcinoma. Seven out of 15 basal cell carcinomas failed to express bad protein. There was no correlation between bad positivity and depth of tumour infiltration. Our observation suggests that the pro-apoptotic bad may function as one ofregulators involved in the maintenance of epidermal homeostasis and this function could be altered depending on the disease state. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:28:22