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Titolo:
Myocardial protection with red wine extract
Autore:
Sato, M; Ray, PS; Maulik, G; Maulik, N; Engelman, RM; Bertelli, AAE; Bertelli, A; Das, DK;
Indirizzi:
Univ Connecticut, Sch Med, Dept Surg, Div Cardiovasc, Farmington, CT 06030USA Univ Connecticut Farmington CT USA 06030 diovasc, Farmington, CT 06030USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Baystate Med Ctr, Springfield, MA USA Baystate Med Ctr Springfield MA USA aystate Med Ctr, Springfield, MA USA Univ Milan, Dept Pharmacol, Milan, Italy Univ Milan Milan ItalyUniv Milan, Dept Pharmacol, Milan, Italy Univ Milan, Inst Anat, Milan, Italy Univ Milan Milan ItalyUniv Milan, Inst Anat, Milan, Italy
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 2, volume: 35, anno: 2000,
pagine: 263 - 268
SICI:
0160-2446(200002)35:2<263:MPWRWE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; MODERATE ALCOHOL-CONSUMPTION; ISCHEMIA-REPERFUSION INJURY; LIPID-PEROXIDATION; CARDIOVASCULAR MORTALITY; PLASMINOGEN-ACTIVATOR; PLATELET-AGGREGATION; FRENCH PARADOX; VITIS-VINIFERA;
Keywords:
ischemia/reperfusion; myocardial infarction; red wine; antioxidant; resveratrol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Das, DK Univ Connecticut, Sch Med, Dept Surg, Div Cardiovasc, Farmington, CT 06030USA Univ Connecticut Farmington CT USA 06030 Farmington, CT 06030USA
Citazione:
M. Sato et al., "Myocardial protection with red wine extract", J CARDIO PH, 35(2), 2000, pp. 263-268

Abstract

Cardioprotective action of red wine was studied by preperfusine isolated rat hearts with ethanol-free red wine extract for 15 min before subjecting them to 30 min of global ischemia followed by 2 h of reperfusion. Four othergroup of rats were studied under identical conditions, of which one servedas control; one was treated with 10 mu M trans-resveratrol (RVT), one of the major antioxidants found in red wines; another, with 0.07% ethanol; and another, with 0.07% ethanol plus 10 mu M RVT. The results of our study demonstrated that both red wine extract and RVT were equally cardioprotective, as evidenced by their abilities to improve postischemic ventricular functions including developed pressure and aortic flow. Developed pressure values at 60 min after reperfusion were 81.8 +/- 1.2 and 68.8 +/- 4.1 mm Hg for the red wine extract and RVT groups, respectively, versus 49.7 +/- 2.7 mm HE for the control group. These compounds also reduced myocardial infarct sizecompared with the control hearts (20.1 +/- 0.5% and 10.5 +/- 0.3% for red wine extract and RVT groups, respectively, vs. 29.9 +/- 3.1% for the control group). The ethanol-treated group displayed slightly better functional recovery, which deteriorated sharply toward the end of the reperfusion period, and the extent of infarction was comparable to that of the control group (31.5 +/- 0.9%). in the ethanol plus RVT group, postischemic contractile function was significantly better than control, and infarct size also was reduced to 20.9 +/- 0.7%. The amount of malonaldehyde formation in the postischemic myocardium was reduced by red wine extract and RVT, indicating a reduction of oxidative stress developed in the ischemic reperfused myocardium. In vitro studies revealed that red wine extract is a potent antioxidant as evidenced by its ability to scavenge peroxyl radical in vitro. Taken together, the results of our study indicate that red wines are cardioprotective by their ability to function as an in vivo antioxidant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:43:31