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Titolo:
Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities
Autore:
Trew, SJ; Wrigley, SK; Pairet, L; Sohal, J; Shanu-Wilson, P; Hayes, MA; Martin, SM; Manohar, RN; Chicarelli-Robinson, MI; Kau, DA; Byrne, CV; Wellington, EMH; Moloney, JM; Howard, J; Hupe, D; Olson, ER;
Indirizzi:
TerraGen Discovery UK Ltd, Slough SL1 4EQ, Berks, England TerraGen Discovery UK Ltd Slough Berks England SL1 4EQ EQ, Berks, England Xenova Ltd, Slough SL1 4EF, Berks, England Xenova Ltd Slough Berks England SL1 4EF d, Slough SL1 4EF, Berks, England Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA Warner Lambert Parke Davis Ann Arbor MI USA 48105 Ann Arbor, MI 48105 USA Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England Univ Warwick Coventry W Midlands England CV4 7AL 7AL, W Midlands, England Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England Univ Durham Durham England DH1 3LE em, Sci Labs, Durham DH1 3LE, England
Titolo Testata:
JOURNAL OF ANTIBIOTICS
fascicolo: 1, volume: 53, anno: 2000,
pagine: 1 - 11
SICI:
0021-8820(200001)53:1<1:NSFSRW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; 2-COMPONENT; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Trew, SJ TerraGen Discovery UK Ltd, 545 Ipswich Rd, Slough SL1 4EQ, Berks,England TerraGen Discovery UK Ltd 545 Ipswich Rd Slough Berks England SL1 4EQ
Citazione:
S.J. Trew et al., "Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities", J ANTIBIOT, 53(1), 2000, pp. 1-11

Abstract

A series of halogenated pyrrolo [2,1-b] [1,3] benzoxazines (1 similar to 9) was isolated from fermentations of an actinomycete strain X10/78/978 (NCIMB40808), identified as Streptomyces rimosus, during a microbial extract screening programme to identify inhibitors of bacterial histidine kinase. Thestructures of these compounds were elucidated by spectroscopic methods including the HMQC, HMBC and INADEQUATE NMR experiments. The structure of 1 was confirmed by X-ray crystallographic studies. Compounds 5 and 6 were produced in fermentations in the presence of NaBr and NaI respectively. The mostabundant member of the series, streptopyrrole, 1, inhibited the nitrogen regulator II (NRII) histidine kinase from Escherichia roll with an IC50 of 20 mu M and exhibited antimicrobial activity against a range of bacteria andfungi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:40:08