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Titolo:
Double irradiation for macroscopic radioresistance or recurrence of melanomas of the posterior uvea: clinical, ballistic, therapeutic and prognostic aspects: a series of 19 cases among 462 patients
Autore:
Grange, JD; Duquesne, N; Roubeyrol, F; Branisteanu, D; Sandon, K; Fleury, J; Gerard, JP; Chauvel, P; Pinzaru, G; Jean-Louis, B; Bievelez, B;
Indirizzi:
Univ Lyon, Clin Ophtalmol, Hop Croix Rousse, F-69004 Lyon, France Univ Lyon Lyon France F-69004 ol, Hop Croix Rousse, F-69004 Lyon, France
Titolo Testata:
JOURNAL FRANCAIS D OPHTALMOLOGIE
fascicolo: 10, volume: 22, anno: 1999,
pagine: 1054 - 1063
SICI:
0181-5512(199912)22:10<1054:DIFMRO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
FRE
Soggetto:
PROTON-BEAM IRRADIATION;
Keywords:
double irradiation; 106 ruthenium; betaraysbrachytherapy; protons; proton-beamtherapy; uveal melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Grange, JD Univ Lyon, Clin Ophtalmol, Hop Croix Rousse, 93 Grande Rue, F-69004 Lyon, France Univ Lyon 93 Grande Rue Lyon France F-69004 69004 Lyon, France
Citazione:
J.D. Grange et al., "Double irradiation for macroscopic radioresistance or recurrence of melanomas of the posterior uvea: clinical, ballistic, therapeutic and prognostic aspects: a series of 19 cases among 462 patients", J FR OPHTAL, 22(10), 1999, pp. 1054-1063

Abstract

We describe two comparative series of patients treated with double-dose betaraysbrachy-therapy (106 Ruthenium) between 1983 and 1994, and double-doseprotonbeam therapy between 1991 and 1996. The indications for double-dose irradiation with the same radioelement correspounded to "macroscopically abnormal" situations: immediate and prolonged radioresistance, recurrence or secondary radioresistance. Thirteen cases are called serie 1 (Ruthenium) and 6 cases are called serie Z (protons). The series 1 allows a more reliablestudy as far as follow-up is higher (5.8 to 7.5 years) than in series 2 where the follow-up is shorter (13.6 to 29 months). Although double-dose irradiation was macroscopically efficient in 1 1 out of 13 cases in series 1, and in 3 out of 6 cases in series 2:(stabilization or decrease of tumour height measured before the second therapeutic session), 2 patients are deceased and 1 has a metastatic disease in the group "recurrence" of Ruthenium serie. Another one has also a metastatic desease in the group "recurrence" of protons serie,; Nevertheless double-dose radiotherapy allows a complementary decrease or stabilization of tumour height after a first session. It alsodecreases the indications for enucleation ii there is no severe anatomic complications, when a tumour does not regress or recurs after a first session of radiations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:46:47