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Titolo:
Exercise and insulin sensitivity: A review
Autore:
Borghouts, LB; Keizer, HA;
Indirizzi:
Maastricht Univ, Dept Movement Sci, NL-6200 MD Maastricht, Netherlands Maastricht Univ Maastricht Netherlands NL-6200 MD aastricht, Netherlands
Titolo Testata:
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
fascicolo: 1, volume: 21, anno: 2000,
pagine: 1 - 12
SICI:
0172-4622(200001)21:1<1:EAISAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; HUMAN SKELETAL-MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; RECEPTOR SUBSTRATE-1 PHOSPHORYLATION; GLUCOSE-TRANSPORTER TRANSLOCATION; SIGNAL-TRANSDUCTION PATHWAY; DOSE-RESPONSE RELATIONSHIP; GLUT-4 PROTEIN-CONTENT; FATTY-ACID METABOLISM; OBESE NIDDM PATIENTS;
Keywords:
skeletal muscle; GLUT4; diabetes; insulin resistance; physical training;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Borghouts, LB Maastricht Univ, Dept Movement Sci, POB 616, NL-6200 MD Maastricht, Netherlands Maastricht Univ POB 616 Maastricht Netherlands NL-6200MD s
Citazione:
L.B. Borghouts e H.A. Keizer, "Exercise and insulin sensitivity: A review", INT J SP M, 21(1), 2000, pp. 1-12

Abstract

Physical activity has a beneficial effect on insulin sensitivity in normalas well as insulin resistant populations. A distinction should be made between the acute effects of exercise and genuine training effects. Up to two hours after exercise, glucose uptake is in part elevated due to insulin independent mechanisms, probably involving a contraction-induced increase in the amount of GLUT4 associated with the plasma membrane and T-tubules. However, a single bout of exercise can increase insulin sensitivity for at least16 h post exercise in healthy as well as NIDDM subjects. Recent studies have accordingly shown that acute exercise also enhances insulin stimulated GLUT4 translocation. Increases in muscle GLUT4 protein content contribute tothis effect, and in adddition it has been hypothesized that the depletion of muscle glycogen stores with exercise plays a role herein. Physical training potentiates the effect of exercise on insulin sensitivity through multiple adaptations in glucose transport and metabolism. in addition, training may elicit favourable changes in lipid metabolism and can bring about improvements in the regulation of hepatic glucose output, which is especially relevant to NIDDM. It is concluded that physical training can be considered to play an important, if not essential role in the treatment and prevention of insulin insensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:26:55