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Titolo:
Alpha(1)-acid glycoprotein (AAG) and serum protein binding of methadone inheroin addicts with abstinence syndrome
Autore:
Garrido, MJ; Aguirre, C; Troconiz, IF; Marot, M; Valle, M; Zamacona, MK; Calvo, R;
Indirizzi:
Univ Pais Vasco, Dept Farmacol, Fac Med, E-48940 Leioa, Vizcaya, Spain Univ Pais Vasco Leioa Vizcaya Spain E-48940 E-48940 Leioa, Vizcaya, Spain Galdakao Hosp, Dept Psychiat, Galdakao, Vizcaya, Spain Galdakao Hosp Galdakao Vizcaya Spain Psychiat, Galdakao, Vizcaya, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
fascicolo: 1, volume: 38, anno: 2000,
pagine: 35 - 40
SICI:
0946-1965(200001)38:1<35:AG(ASP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-1-ACID GLYCOPROTEIN; MAINTENANCE TREATMENT; PLASMA; WITHDRAWAL; PHARMACOKINETICS; PAIN;
Keywords:
alpha(1)-acid glycoprotein; methadone; protein-binding; abstinence syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Calvo, R Univ Pais Vasco, Dept Farmacol, Fac Med, E-48940 Leioa, Vizcaya, Spain Univ Pais Vasco Leioa Vizcaya Spain E-48940 eioa, Vizcaya, Spain
Citazione:
M.J. Garrido et al., "Alpha(1)-acid glycoprotein (AAG) and serum protein binding of methadone inheroin addicts with abstinence syndrome", INT J CL PH, 38(1), 2000, pp. 35-40

Abstract

Objective: To quantify serum protein levels and protein-binding of methadone in vitro in heroin-addicted patients showing objective signs of heroin abstinence. Subjects and methods: Serum samples were obtained from patients (n = 27) hospitalized to participate in a methadone detoxification program and from healthy volunteers (n = 21). The severity of the abstinence syndrome was assessed before blood sampling using a standardized scale. Concentrations of both albumin and alpha(1)-acid glycoprotein (AAG) were measured inall serum samples. The protein-binding of alpha(1)-methadone was determined by the ultrafiltration technique and the unbound concentration was measured by liquid scintillation counting. Results: The mean of the AAG concentrations was significantly increased in patients showing signs of withdrawal while the albumin concentrations did not change. Also, the unbound methadonewas significantly decreased in this group when compared to the control. A positive correlation (Pearson r = 0.48; p < 0.005) indicates that AAG levels rise during abstinence as the score of withdrawal symptoms increases. Additionally, pooled data from all individuals show the binding of methadone to be related to AAG (r = 0.46. p < 0.05) levels and not to albumin. Conclusions: The observed changes in protein-binding in abstinence individuals suggest the need for increased dosages of methadone when such patients are treated. Levels of AAG or protein-binding appear to be components of the interindividual variance observed in the response to methadone treatment, hence these variables could be included in future kinetic and dynamic studies.

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Documento generato il 09/04/20 alle ore 07:35:24