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Titolo:
The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy
Autore:
Baltatu, O; Silva, JA; Ganten, D; Bader, M;
Indirizzi:
Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13092 D-13092 Berlin, Germany
Titolo Testata:
HYPERTENSION
fascicolo: 1, volume: 35, anno: 2000,
parte:, 2 supplemento:, S
pagine: 409 - 412
SICI:
0194-911X(200001)35:1<409:TBRSMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FLUID HOMEOSTASIS; LONG-TERM CONTROL; LAMINA-TERMINALIS; AREA POSTREMA; RATS; EXPRESSION; PRESSURE;
Keywords:
renin-angiotensin system; collagen; angiotensin II; hypertrophy; atrial natriuretic peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Baltatu, O Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13092 Berlin,Germany Max Delbruck Ctr Mol Med Robert Rossle Str 10 Berlin Germany D-13092
Citazione:
O. Baltatu et al., "The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy", HYPERTENSIO, 35(1), 2000, pp. 409-412

Abstract

The potential involvement of the brain renin-angiotensin system in the hypertension induced by subpressor doses of angiotensin II was tested by the use of newly developed transgenic rats with permanent inhibition of brain angiotensinogen synthesis [TGR(ASrAOGEN)]. Basal systolic blood pressure monitored by telemetry was significantly lower in TGR(ASrAOGEN) than in Sprague-Dawley rats (parent strain) (122.5+/-1.5 versus 128.9+/-1.9 mmHg, respectively; P<0.05). The increase in systolic blood pressure induced by 7 days ofchronic angiotensin II infusion was significantly attenuated in TGR(ASrAOGEN) in comparison with control rats (29.8+/-4.2 versus 46.3+/-2.5 mm Hg, respectively; P<0.005). Moreover, an increase in heart/body weight ratio was evident only in Sprague-Dawley (11.1%) but not in TGR(ASrAOGEN) rats (2.8%). In contrast, mRNA levels of atrial natriuretic peptide (ANP) and collagenIII in the left ventricle measured by ribonuclease protection assay were similarly increased in both TGR(ASrAOGEN) (ANP, X2.5; collagen III, X1.8) and Sprague-Dawley rats (ANP, X2.4; collagen III, X2) as a consequence of angiotensin II infusion. Thus, the expression of these genes in the left ventricle seems to be directly stimulated by angiotensin II, However, the hypertensive and hypertrophic effects of subpressor angiotensin II are at least in part mediated by the brain renin-angiotensin system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:42:10