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Titolo:
Catenins and their associated proteins in colorectal cancer
Autore:
Tucker, EL; Pignatelli, M;
Indirizzi:
Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon,England Univ Bristol Bristol Avon England BS8 1TD , Bristol BS8 1TD, Avon,England
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 1, volume: 15, anno: 2000,
pagine: 251 - 260
SICI:
0213-3911(200001)15:1<251:CATAPI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; TUMOR-SUPPRESSOR PROTEIN; TYROSINE KINASE SUBSTRATE; INTESTINAL TREFOIL FACTOR; GROWTH-FACTOR RECEPTOR; BETA-CATENIN; E-CADHERIN; ALPHA-CATENIN; EPITHELIAL-CELLS; CROSS-TALK;
Keywords:
cadherins; APC; EGFR; cell adhesion; cell signalling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Pignatelli, M Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Univ Walk, Bristol BS81TD, Avon, England Univ Bristol Univ Walk Bristol Avon England BS8 1TD England
Citazione:
E.L. Tucker e M. Pignatelli, "Catenins and their associated proteins in colorectal cancer", HIST HISTOP, 15(1), 2000, pp. 251-260

Abstract

Colorectal cancer is the second most common cause of cancer mortality in the western world. Colorectal cancer has been well studied? and the genetic steps involved in the adenoma to carcinoma sequence have been well elucidated. The first genetic alteration, found in 85% of adenomas, are mutations in the adenomatous polyposis coli (APC) gene. However, the consequences of this and the exact function of APC in the colon is not fully understood. It has been suggested that APC could function through its regulation of beta-catenin, an ubiquitous cytoskeletal protein with multiple binding specificities resulting in diverse functions including cell growth, adhesion, and migration. Any change in these associations may play a role in colorectal cancer development and progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:37:46