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Titolo:
Clozapine dose-concentration relationships in plasma, hair and sweat specimens of schizophrenic patients
Autore:
Cirimele, V; Kintz, P; Gosselin, O; Ludes, B;
Indirizzi:
Inst Med Legale, F-67085 Strasbourg, France Inst Med Legale Strasbourg France F-67085 le, F-67085 Strasbourg, France CHU Nancy, Serv Psychol Med, F-54201 Toul, France CHU Nancy Toul France F-54201 cy, Serv Psychol Med, F-54201 Toul, France
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 1-3, volume: 107, anno: 2000,
pagine: 289 - 300
SICI:
0379-0738(20000110)107:1-3<289:CDRIPH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; ULTRAVIOLET DETECTION; CLINICAL-RESPONSE; HUMAN SERUM; DRUGS; PATCH; AGRANULOCYTOSIS; NORCLOZAPINE; METABOLITES;
Keywords:
clozapine; sweat; hair; analytical procedures; monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Cirimele, V Inst Med Legale, 11 Rue Humann, F-67085 Strasbourg, France Inst Med Legale 11 Rue Humann Strasbourg France F-67085 rance
Citazione:
V. Cirimele et al., "Clozapine dose-concentration relationships in plasma, hair and sweat specimens of schizophrenic patients", FOREN SCI I, 107(1-3), 2000, pp. 289-300

Abstract

The aim of the present study was to establish an analytical method for thedetermination of clozapine in sweat and to determine whether the clozapinelevel in hair and sweat were correlated to the daily dose of clozapine delivered to patients. Twenty-six subjects treated with clozapine at 200-700 mg/day for refractory psychosis were included in the study. Clozapine was determined in plasma by liquid chromatography coupled to a diode array detection system, after extraction with an organic solvent at pH 9.5. Clozapine was extracted from hair and sweat patches specimens by incubation in methanol overnight at 40 degrees C. The residues were analyzed by gas chromatography coupled to mass spectrometry in the electronic impact mode of detection. It was possible to determine clozapine in concentrations ranging from 30 to 1016 ng/ml in plasma (n=22), from 0.17 to 34.24 ng/mg in hair (n=23) and from 49 to 5609 ng/ patch in sweat (n=20). Preliminary results suggest a lack of correlation between daily regimen of clozapine and plasma levels of the drug. Therefore, a better dose-concentration relationship was observed in our study between daily dose and hair concentration (r=0.542, P<7%) or between daily dose and sweat concentration (r=0.589, P<6%), but with wide variations for patients at the same posology. However, the idea of using quantitative drug measurements in hair or sweat to ascertain whether a patient has taken his treatment exactly as prescribed will remain inapplicable. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 15:13:46