Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of endonucleases in renal tubular epithelial cell injury
Autore:
Ueda, N; Shah, SV;
Indirizzi:
Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA JL McClellan Mem VA Hosp, Little Rock, AR USA JL McClellan Mem VA Hosp Little Rock AR USA VA Hosp, Little Rock, AR USA
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 1, volume: 8, anno: 2000,
pagine: 8 - 13
SICI:
1018-7782(200001/02)8:1<8:ROEIRT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL HYPOXIC INJURY; INDUCED DNA-DAMAGE; INDUCED APOPTOSIS; ALLOGRAFT REJECTION; OXIDANT INJURY; MESSENGER-RNA; LLC-PK1 CELLS; EXPRESSION; DEATH; KIDNEY;
Keywords:
cell death; endonucleases; reactive oxygen metabolites; caspases; ceramide; renal tubular epithelial cells; acute renal failure;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Shah, SV Univ Arkansas Med Sci, Dept Med, 4301 W Markham,Slot 501, Little Rock, AR 72205 USA Univ Arkansas Med Sci 4301 W Markham,Slot 501 Little Rock AR USA 72205
Citazione:
N. Ueda e S.V. Shah, "Role of endonucleases in renal tubular epithelial cell injury", EXP NEPHROL, 8(1), 2000, pp. 8-13

Abstract

The study of cell death has emerged as an important and exciting area of research in cell biology; Although two kinds of cell death, apoptosis and necrosis, are recognized, one of the major advances in our understanding of cell death has been the recognition that the pathways traditionally associated with apoptosis may be very critical in the form of cell injury associated with necrosis. Renal tubular epithelial cell injury from ischemia or toxins has generally been regarded as a result of a necrotic form of cell death, We briefly describe recent evidence indicating apoptotic mechanisms including endonuclease activation in renal tubular injury and some mediators (oxidants, caspases and ceramide) which regulate this process, The pathway that is followed by the cell is dependent on both the nature and severity of insults, and it is likely that the cascades that lead to the apoptotic or necrotic mode of cell death are activated almost simultaneously and may sharesome common pathways. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:22:45