Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHRONIC TREATMENT WITH SYSTEMIC MORPHINE-INDUCED TOLERANCE TO THE SYSTEMIC AND PERIPHERAL ANTINOCICEPTIVE EFFECTS OF MORPHINE ON BOTH CARRAGEENAN-INDUCED MECHANICAL HYPERALGESIA AND SPINAL C-FOS EXPRESSION IN AWAKE RATS
Autore:
HONORE P; CATHELINE G; LEGUEN S; BESSON JM;
Indirizzi:
INSERM U161,2 RUE DALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Pain
fascicolo: 1, volume: 71, anno: 1997,
pagine: 99 - 108
SICI:
0304-3959(1997)71:1<99:CTWSMT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADJUVANT-INDUCED ARTHRITIS; ENHANCES AXONAL-TRANSPORT; MU-OPIOID RECEPTORS; ANALGESIC ACTIVITY; PROSTAGLANDIN HYPERALGESIA; CONTINUOUS INFUSION; CROSS-TOLERANCE; CORD NEURONS; INFLAMMATION; IMMUNOREACTIVITY;
Keywords:
C-FOS; SPINAL CORD; INTRAPLANTAR MORPHINE; TOLERANCE; MECHANICAL HYPERALGESIA; CARRAGEENAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "CHRONIC TREATMENT WITH SYSTEMIC MORPHINE-INDUCED TOLERANCE TO THE SYSTEMIC AND PERIPHERAL ANTINOCICEPTIVE EFFECTS OF MORPHINE ON BOTH CARRAGEENAN-INDUCED MECHANICAL HYPERALGESIA AND SPINAL C-FOS EXPRESSION IN AWAKE RATS", Pain, 71(1), 1997, pp. 99-108

Abstract

The effects of intravenous (3 mg/kg i.v.) and intraplantar (50 mu g/50 mu l i.pl.) morphine were investigated on spinal c-Fos expression induced 2 h after intraplantar carrageenin (6 mg/150 mu l of saline) andon carrageenin (2 mg/150 mu l of saline) induced mechanical hyperalgesia, at day 4, in both naive and chronic morphine treated (80 mg/kg/day s.c. on days 1, 2 and 3) rats. In naive rats, i.v. and i.pl. morphine significantly decreased spinal c-Fos expression (64 +/- 4% and 44 +/- 4% reduction of control carrageenin c-Fos expression, P < 0.0001 forboth, respectively) and mechanical hyperalgesia (maximal increase: 326 +/- 29%, P < 0.0001 and 87 +/- 5%, P < 0.005 of control carrageenin paw pressure vocalisation threshold (VTPP), respectively), which only developed in the carrageenin injected paw. Both treatments were ineffective in chronic morphine treated rats (92 +/- 9% and 106 +/- 6% of control carrageenin c-Fos expression; 33 +/- 17% and 30 +/- 15% increaseof control carrageenin VTPP, respectively). Furthermore, only i.v. morphine increased the VTPP in the contralateral paw, in naive rats (maximal increase: 90 +/- 8%, P < 0.0001 of control carrageenin VTPP), itseffects being significantly less pronounced than for the inflamed paw(P < 0.0001). These studies based on spinal c-Fos expression as an indirect marker of spinal nociceptive processes and on behavioural experiments clearly revealed that chronic treatment with systemic morphine induced tolerance to both its systemic and peripheral effects. (C) 1997 International Association for the Study of Pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:52:39