Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF THE BRADYKININ B-1 RECEPTOR ANTAGONIST DES-ARG(9)[LEU(8)]BRADYKININ AND GENETIC DISRUPTION OF THE B-2 RECEPTOR ON NOCICEPTION INRATS AND MICE
Autore:
RUPNIAK NMJ; BOYCE S; WEBB JK; WILLIAMS AR; CARLSON EJ; HILL RG; BORKOWSKI JA; HESS JF;
Indirizzi:
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,RES LABS,TERLINGS PK HARLOW CM20 2QR ESSEX ENGLAND MERCK RES LABS RAHWAY NJ 07065
Titolo Testata:
Pain
fascicolo: 1, volume: 71, anno: 1997,
pagine: 89 - 97
SICI:
0304-3959(1997)71:1<89:EOTBBR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTINOCICEPTIVE ACTIVITY; MECHANICAL HYPERALGESIA; CHRONIC INFLAMMATION; PAIN RESPONSE; FORMALIN TEST; IN-VIVO; INDUCTION; KININS; MODEL; B1;
Keywords:
BRADYKININ B-1 AND B-2 RECEPTORS; TRANSGENIC MOUSE; FORMALIN PAW; CARRAGEENAN; FREUNDS ADJUVANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
N.M.J. Rupniak et al., "EFFECTS OF THE BRADYKININ B-1 RECEPTOR ANTAGONIST DES-ARG(9)[LEU(8)]BRADYKININ AND GENETIC DISRUPTION OF THE B-2 RECEPTOR ON NOCICEPTION INRATS AND MICE", Pain, 71(1), 1997, pp. 89-97

Abstract

The contributions of B-1 and B-2 bradykinin receptors to acute and chronic inflammatory hyperalgesia were examined using the peptide B-1 receptor antagonist des-Arg(9)[leu(8)]bradykinin and transgenic Bk2r(+) mice. In normal rats and mice, des-Arg(9)[Leu(8)]bradykinin (30 nmol/kg i.v. or s.c.) inhibited carrageenan-induced hyperalgesia and the late phase nociceptive response to formalin. The active dose range was narrow, suggesting partial agonist activity of this peptide. In rats with monoarthritis, des-Arg(9)[leu(8)]bradykinin (up to 30 nmol/kg i.v.) failed to reduce the number of vocalisations elicited by gentle flexion and extension of the inflamed limb; however, hyperalgesia was exacerbated by administration of the B-1 receptor agonist des-[Arg(9)]bradykinin (100 nmol/kg i.v.), consistent with other evidence for local induction of B-1 receptors during adjuvant-induced arthritis. The nociceptive response to intraplantar injection of bradykinin (10 nmol) and hyperalgesia induced by carrageenan (0.6 mg) were absent in Bk2r(+) mice,indicating that stimulation of B-2 receptors is an essential step in the initiation of some nociceptive and inflammatory reactions. However, the nociceptive response to formalin (2.5% intraplantar), including inhibition of the late phase by des-Arg(9)[Leu(8)]bradykinin (0.3 nmol), and induction of thermal hyperalgesia by Freund's adjuvant (0.1%) appeared intact in Bk2r(+) mice. These findings support other evidence for an involvement of B-1 receptors in inflammatory hyperalgesia and suggest that B-1 receptor antagonists may be clinically useful as anti-inflammatory and analgesic drugs. (C) 1997 International Association for the Study of Pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:20:02