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Titolo:
INHIBITION OF THE BLINK REFLEX R2 COMPONENT AFTER SUPRAORBITAL AND INDEX FINGER STIMULATIONS IS REDUCED IN CLUSTER HEADACHE - AN INDICATIONFOR BOTH SEGMENTAL AND SUPRASEGMENTAL DYSFUNCTION
Autore:
LOZZA A; SCHOENEN J; DELWAIDE PJ;
Indirizzi:
UNIV LIEGE,DEPT NEUROL,CHR CITADELLE,BLD 12EME LIGNE 1 B-4000 LIEGE BELGIUM UNIV LIEGE,DEPT NEUROL,CHR CITADELLE B-4000 LIEGE BELGIUM
Titolo Testata:
Pain
fascicolo: 1, volume: 71, anno: 1997,
pagine: 81 - 88
SICI:
0304-3959(1997)71:1<81:IOTBRR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORBICULARIS OCULI REFLEX; EXTEROCEPTIVE SUPPRESSION; PERIAQUEDUCTAL GRAY; PREPULSE INHIBITION; BRAIN-STEM; NUCLEUS; NEURONS; RAT; MEDIATION; STIMULI;
Keywords:
CLUSTER HEADACHE; BLINK REFLEX; R2 COMPONENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A. Lozza et al., "INHIBITION OF THE BLINK REFLEX R2 COMPONENT AFTER SUPRAORBITAL AND INDEX FINGER STIMULATIONS IS REDUCED IN CLUSTER HEADACHE - AN INDICATIONFOR BOTH SEGMENTAL AND SUPRASEGMENTAL DYSFUNCTION", Pain, 71(1), 1997, pp. 81-88

Abstract

Peripheral as well as central mechanisms are thought to play a role in cluster headache pathogenesis. We have studied recovery curves of the R2 component of the blink reflex after conditioning by supraorbital or index finger stimuli in 10 episodic cluster headache (CH) patients during a cluster period and in 10 healthy controls. There was no significant change of R2 threshold, latency or area in CH patients. After paired supraorbital stimuli, R2 recovered more rapidly in patients on the symptomatic side. After index stimulations, R2 recovery was more rapid on both symptomatic and non-symptomatic sides in patients comparedto controls. Naloxone (0.4 mg) i.v. in two subjects partially reversed the R2 suppression induced by index finger stimuli. The unilateral decrease of R2 inhibition after a segmental supraorbital stimulus most likely reflects sensitisation in the spinal trigeminal nucleus. Whether the latter is due to irritation of the ophthalmic nerve within the cavernous sinus region, which is thought to be pivotal in CH pathogenesis, remains to be proven. In addition, we propose that the bilateral deficit of R2 inhibition after an extrasegmental exteroceptive stimulusmight reflect hypoactivity of reticular nuclei, possibly because of reduced central opioid activity. (C) 1997 International Association forthe Study of Pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:25:29