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Titolo:
Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle
Autore:
Casis, O; Gallego, M; Iriarte, M; Sanchez-Chapula, JA;
Indirizzi:
Univ Basque Country, Sch Pharm, Dept Physiol, Bilbao 48080, Spain Univ Basque Country Bilbao Spain 48080 Dept Physiol, Bilbao 48080, Spain Fdn Res & Teaching Cardiovasc Dis, Bilbao, Spain Fdn Res & Teaching Cardiovasc Dis Bilbao Spain ovasc Dis, Bilbao, Spain Univ Colima, Univ Ctr Biomed Res, Colima, Mexico Univ Colima Colima Mexico v Colima, Univ Ctr Biomed Res, Colima, Mexico
Titolo Testata:
DIABETOLOGIA
fascicolo: 1, volume: 43, anno: 2000,
pagine: 101 - 109
SICI:
0012-186X(200001)43:1<101:EODCOR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT OUTWARD CURRENT; QT INTERVAL PROLONGATION; POTASSIUM CURRENTS; AUTONOMIC NEUROPATHY; ACTION-POTENTIALS; K+ CURRENTS; MYOCYTES; CALCIUM; HETEROGENEITY; MELLITUS;
Keywords:
patch-clamp; potassium currents; diabetes; action potential; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Casis, O Univ Basque Country, Sch Pharm, Dept Physiol, POB 699, Bilbao 48080, Spain Univ Basque Country POB 699 Bilbao Spain 48080 lbao 48080, Spain
Citazione:
O. Casis et al., "Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle", DIABETOLOG, 43(1), 2000, pp. 101-109

Abstract

Aims/hypothesis. To identify the possible causes of the lengthening of theaction potential duration described in patients affected by diabetes mellitus. Methods. We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents I-to, I-K, I-ss and I-K1 in enzymatically isolated myocytes from three different regions of ratheart: total right ventricle, subepicardium at the apex of the left ventricle and subendocardium at the base of the left ventricle,Results. No changes in I-K1 were found due to diabetes, but there was a uniform decrease in I-to (50%) and I-ss (40%) current densities in the three regions. In contrast, I-K diminished unevenly, with the greatest decrease in the subendocardium at the base of the left ventricle (48%), followed by the subepicardium at the apex of the left ventricle (32%) and right ventricle (10%). Conclusion/interpretation. These findings suggest the existence of regional differences in ion channel expression associated with diabetes. The decrease of these repolarising currents could account for the lengthening of action potential and the consequent change in the Q-T interval of the ECG observed in diabetic rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:13:47