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Titolo:
Event-related potential and EEG measures in Parkinson's disease without and with dementia
Autore:
Tanaka, H; Koenig, T; Pascual-Marqui, RD; Hirata, K; Kochi, K; Lehmann, D;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Neurol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 urol, Mibu, Tochigi 3210293, Japan Univ Hosp Psychiat, Key Inst Brain Mind Res, Zurich, Switzerland Univ HospPsychiat Zurich Switzerland ain Mind Res, Zurich, Switzerland
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 1, volume: 11, anno: 2000,
pagine: 39 - 45
SICI:
1420-8008(200001/02)11:1<39:EPAEMI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINI-MENTAL-STATE; FOLLOW-UP; COMPONENTS; P300; MECHANISMS; FREQUENCY;
Keywords:
multichannel EEG; event-related potential paradigm; Parkinson's disease; intellectual impairment; dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, H Dokkyo Univ, Sch Med, Dept Neurol, Kitakobayashi 880, Mibu, Tochigi 3210293, Japan Dokkyo Univ Kitakobayashi 880 Mibu Tochigi Japan 3210293, Japan
Citazione:
H. Tanaka et al., "Event-related potential and EEG measures in Parkinson's disease without and with dementia", DEMENT G C, 11(1), 2000, pp. 39-45

Abstract

Nondemented Parkinson's disease (PD) patients showed increased amplitude of event-related potential component P3. We recorded 18-channel spontaneous eyes-closed resting EEG and auditory oddball event-related potentials in 29PD patients and 11 age-matched controls. Combining Mini-Mental State Examination score and oddball P3 counting performance, 15 patients were intellectually normal, 7 moderately, and 7 severely demented. P3 and N1 amplitude and latency, mean amplitude of 1,024 ms post-stimulus (separate after rare and after frequent stimuli), and resting EEG total power for 40 s were computed, a nd linearly regressed for age, sex, and L-dopa dosage. In nondemented PD patients, increased P3 amplitude was confirmed, but N1 amplitude and mean amplitude after rare and frequent stimuli were also increased as well as - most important - resting EEG total power. With increasing dementia, amplitude and power decreased, and P3 latency increased. Task demands cannot explain increased P3 amplitude, since similarly increased EEG total power was found during no-task resting. Prospective studies must determine whether P3 amplitude and EEG power in nondemented PD patients can serve as predictors of dementia. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:07:29