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Titolo:
Dementia and antiphospholipid antibodies
Autore:
Mosek, A; Yust, I; Treves, TA; Vardinon, N; Korczyn, AD; Chapman, J;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Med Ctr, Dept Neurol, Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel Med Ctr, Dept Neurol, Tel Aviv, Israel Tel Aviv Med Ctr, Dept Med A, Tel Aviv, Israel Tel Aviv Med Ctr Tel AvivIsrael Med Ctr, Dept Med A, Tel Aviv, Israel Tel Aviv Med Ctr, Immunol Unit, Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel ed Ctr, Immunol Unit, Tel Aviv, Israel
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 1, volume: 11, anno: 2000,
pagine: 36 - 38
SICI:
1420-8008(200001/02)11:1<36:DAAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICARDIOLIPIN ANTIBODIES; LUPUS ANTICOAGULANT; CARDIOLIPIN; STROKE;
Keywords:
dementia; aging; vascular dementia; Alzheimer's disease; primary degenerative dementia; antiphospholipid antibodies; cardiolipin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Korczyn, AD Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 9978 Tel Aviv, Israel
Citazione:
A. Mosek et al., "Dementia and antiphospholipid antibodies", DEMENT G C, 11(1), 2000, pp. 36-38

Abstract

Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia, We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 years old), residents of an old age home who were not overtly demented. Levels of aPLAb were measured by a standardized ELISA, utilizing cardiolipin as antigen, and we considered levels above 20 IgG antiphospholipid units (GPLU) as significantly elevated. We found that 5 of the 87demented patients (6%), but none of the 69 controls, had significantly elevated aPLAb levels (p = 0.03, one-tailed Fisher's exact test). All the patients with high aPLAb levels were diagnosed clinically as having dementia ofthe Alzheimer type, except for 1 who had mixed dementia, and none had features of an immune-mediated disease. Thus, a small but significant number ofpatients with dementia have high levels of aPLAb. The role of the aPLAb inthese patients, with apparently diffuse brain disease, is currently unknown. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 15/07/20 alle ore 07:48:42