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Titolo:
Dysfunction of small myelinated afferents in diabetic polyneuropathy, as assessed by laser evoked potentials
Autore:
Agostino, R; Cruccu, G; Romaniello, A; Innocenti, P; Inghilleri, M; Manfredi, M;
Indirizzi:
Univ Rome La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy Univ Rome La Sapienza Rome Italy I-00185 Neurol Sci, I-00185 Rome, Italy Antidiabet Ctr ACISMOM, Rome, Italy Antidiabet Ctr ACISMOM Rome ItalyAntidiabet Ctr ACISMOM, Rome, Italy Ist Regina Elena, I-00161 Rome, Italy Ist Regina Elena Rome Italy I-00161 st Regina Elena, I-00161 Rome, Italy Neuromed Inst, Pozzilli, Italy Neuromed Inst Pozzilli ItalyNeuromed Inst, Pozzilli, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 111, anno: 2000,
pagine: 270 - 276
SICI:
1388-2457(200002)111:2<270:DOSMAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CO2-LASER STIMULATION; VIBRATION SENSATION; BRAIN POTENTIALS; PAIN; NEUROPATHY; FIBER; THRESHOLDS; VARIABILITY; INVOLVEMENT; PERCEPTION;
Keywords:
diabetic polyneuropathy; laser evoked potentials; small-diameter nerve fibers; sensory function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Cruccu, G Univ Rome La Sapienza, Dept Neurol Sci, Viale Univ 30, I-00185 Rome, Italy Univ Rome La Sapienza Viale Univ 30 Rome Italy I-00185 e, Italy
Citazione:
R. Agostino et al., "Dysfunction of small myelinated afferents in diabetic polyneuropathy, as assessed by laser evoked potentials", CLIN NEU, 111(2), 2000, pp. 270-276

Abstract

Objective: To verify whether laser evoked potentials are useful in assessing the function of small afferent fibers and to compare dysfunction of large and small afferent fibers in patients with diabetic polyneuropathy. Methods: The brain potentials evoked by CO2 laser stimulation of the hand and foot were studied in diabetic patients (n = 45) with various degrees ofperipheral nerve damage. Laser evoked potentials (which assess the function of small myelinated afferents) were also compared with ulnar and sural nerve sensory action potentials (which assess the function of large myelinated afferents) by scoring the abnormalities of the two neurophysiological tests with similar criteria. Results: Laser evoked potentials were often absent: the mean latency was normal and mean amplitude decreased, as expected in axonopathies. Although clinical examination showed more frequent impairment of vibratory than pinprick sensation, laser evoked potentials and sensory action potentials yielded similar abnormality scores and showed a strong intra-individual correlation. Conclusions: Laser evoked potentials, possibly better than standard clinical examination for assessing the abnormalities of small-diameter afferents,indicate that diabetic polyneuropathy induces large- and small-afferent dysfunction in parallel. (C) 2000 Published by Elsevier Science ireland Ltd. All rights reserved.

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Documento generato il 15/07/20 alle ore 20:51:54