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Titolo:
Event-related brain potentials in response to novel sounds in dementia
Autore:
Yamaguchi, S; Tsuchiya, H; Yamagata, S; Toyoda, G; Kobayashi, S;
Indirizzi:
Shimane Med Univ, Dept Internal Med 3, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 zumo, Shimane 6938501, Japan
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 111, anno: 2000,
pagine: 195 - 203
SICI:
1388-2457(200002)111:2<195:EBPIRT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; EVOKED-POTENTIALS; SOMATOSENSORY STIMULI; VASCULAR DEMENTIA; SCALP TOPOGRAPHY; TEMPORAL-ORDER; TARGET; P300; LESIONS; CORTEX;
Keywords:
novelty P3; target P3; scalp topography; Alzheimer's disease; vascular dementia; frontal lobe function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, S Shimane Med Univ, Dept Internal Med 3, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 6938501, Japan
Citazione:
S. Yamaguchi et al., "Event-related brain potentials in response to novel sounds in dementia", CLIN NEU, 111(2), 2000, pp. 195-203

Abstract

Objective: Non-target, deviant stimuli generate an earlier latency, front-central novelty P3, whereas correctly detected task-relevant stimuli generate a parietal maximal target P3. We examined whether the P3 component to novel stimuli is affected by dementing processes, and is therefore useful fordistinguishing Alzheimer's type dementia (AD) from vascular dementia (VD). Methods: We recorded ERPs to task-relevant stimuli (target P3) and novel task-irrelevant stimuli (novelty P3) in an auditory oddball task in AD (n = 16), VD (n = 16), and age-matched controls (n = 18). The amplitude, latency, and scalp topography of target and novelty P3 were compared among 3 groups using ANOVA. The relationship between P3 measures and intelligence scoreswere evaluated by correlation analysis. Results: The amplitude, latency and scalp topography of the target P3 werecomparably affected by both AD and VD. However, the amplitude of the novelty P3 was markedly reduced in VD, but not in AD, and the scalp topographicswere different in the 3 groups. The amplitude was maximal at frontal sitesin controls, at central sites in AD, and at parietal sites in VD. The target P3 latency was prolonged in both AD and VD, whereas the novelty P3 latency was only prolonged in VD. AD was discriminated satisfactorily from VD byusing the novelty amplitude at Ct and the ratio of the amplitudes at Fz and Pt as independent variables. Conclusions: These results suggest that the response to novel stimuli is differentially affected by dementia with degenerative and vascular etiology. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:34:40