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Titolo:
Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury in vivo
Autore:
Mruk, JS; Webster, MWI; Heras, M; Reid, JM; Grill, DE; Chesebro, JH;
Indirizzi:
Buchanan Cty Cardiol, St Joseph, MO USA Buchanan Cty Cardiol St Joseph MOUSA nan Cty Cardiol, St Joseph, MO USA Green Lane Hosp, Auckland 3, New Zealand Green Lane Hosp Auckland New Zealand 3 ane Hosp, Auckland 3, New Zealand Hosp Clin Prov Barcelona 1, Barcelona, Spain Hosp Clin Prov Barcelona 1 Barcelona Spain arcelona 1, Barcelona, Spain Mayo Clin & Mayo Fdn, Dept Oncol, Rochester, MN 55905 USA Mayo Clin & MayoFdn Rochester MN USA 55905 ncol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Ctr Comprehens Canc, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Canc, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Biostat, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 stat, Rochester, MN 55905 USA Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 ovasc Inst, New York, NY 10029 USA
Titolo Testata:
CIRCULATION
fascicolo: 3, volume: 101, anno: 2000,
pagine: 324 - 328
SICI:
0009-7322(20000125)101:3<324:FA(PRP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC FLOW VARIATIONS; IB BINDING DOMAIN; ACETIC-ACID; WILLEBRAND-FACTOR; HEMOSTATIC PLUG; RECEPTOR; INVIVO; MECHANISMS; ACTIVATION; INDUCTION;
Keywords:
angioplasty; platelets; platelet aggregation inhibitors; thrombus; vasoconstriction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Chesebro, JH Mt Sinai Med Ctr, Cardiovasc Inst, Box 1030,1 Gustave L Levy Pl, New York,NY 10029 USA Mt Sinai Med Ctr Box 1030,1 Gustave L Levy Pl NewYork NY USA 10029
Citazione:
J.S. Mruk et al., "Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury in vivo", CIRCULATION, 101(3), 2000, pp. 324-328

Abstract

Background-Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumordrug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. Methods and Results-In-111-labeled autologous platelet and I-125-labeled porcine fibrin(ogen) deposition, and the incidence of macroscopic mural thrombosis onto deeply injured artery (tunica media) were compared in 20 pigs (40+/-1 kg [mean+/-SEM], body surface area=1.0+/- m(2)), randomized to FAA bolus (n=10) of 5.5g/m(2), followed by an infusion at 0.14g . m(-2) . min(-1) or placebo (n=10). Vasoconstriction was measured immediately beyond the dilated segment using quantitative angiography, Platelet deposition (X 10(6)/cm(2) of carotid artery) was reduced over 12-fold in pigs treated with FAA(13+/-3 versus 164+/-51, P=0.001) compared with placebo. Fibrin(ogen) deposition (X10(12) molecules/cm(2) of carotid artery) did not significantly differ in FAA-treated pigs versus placebo ( 40+/-8 versus 140+/-69, P=0.08). Large mural thrombi were present in 100% of placebo-treated pigs versus very small thrombi in 40% of FAA-treated pigs (P=0.005), Vasoconstriction was reduced from 46+/-6% in the placebo group to 15+/-3% in the FAA group (P<0.001). Plasma level of FAA before angioplasty was 515+/-23 mu g/mL. The activated partial thromboplastin time was unchanged. The bleeding time was >2SDabove the normal mean in 4 of 5 treated pigs (increased from 157+/-29 to 522+/-123 s). Conclusions-FAA markedly reduced platelet deposition, mural thrombi, and injury-induced vasoconstriction after deep arterial injury, suggesting that a major inhibition of platelet glycoprotein Ib alpha may be beneficial therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:06:03