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Titolo:
Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor
Autore:
Zoldhelyi, P; McNatt, J; Shelat, HS; Yamamoto, Y; Chen, ZQ; Willerson, JT;
Indirizzi:
Texas Heart Inst, Waf Said Mol Cardiol & Gene Therapy Res Lab, Houston, TX77030 USA Texas Heart Inst Houston TX USA 77030 erapy Res Lab, Houston, TX77030 USA Univ Texas, Sch Med, Dept Med Cardiol, Houston, TX USA Univ Texas HoustonTX USA as, Sch Med, Dept Med Cardiol, Houston, TX USA
Titolo Testata:
CIRCULATION
fascicolo: 3, volume: 101, anno: 2000,
pagine: 289 - 295
SICI:
0009-7322(20000125)101:3<289:TOBPCA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ATHEROSCLEROTIC PLAQUES; ADENOVIRUS-MEDIATED TRANSFER; CYCLIC FLOW VARIATIONS; COAGULATION INHIBITOR; CORONARY ANGIOPLASTY; PLATELET DEPOSITION; MODEL; REOCCLUSION; PREVENTION; THROMBOSIS;
Keywords:
angioplasty; cerebrovascular disorders; coagulation; genes; thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Zoldhelyi, P Texas Heart Inst, Waf Said Mol Cardiol & Gene Therapy Res Lab, MC 2-255,1101 Bates St, Houston, TX 77030 USA Texas Heart Inst MC 2-255,1101 Bates St Houston TX USA 77030
Citazione:
P. Zoldhelyi et al., "Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor", CIRCULATION, 101(3), 2000, pp. 289-295

Abstract

Background-Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of factor Xa and the coagulant initiator complex tissue factor/factor VIIa. Methods and Results-To study the effects of TFPI gene transfer on thrombusformation, balloon-injured porcine carotid arteries were treated locally with an adenovirus encoding human TFPI (Ad-TFPI) or control virus. Gene transfer of TFPI was confirmed by detection of human TFPI in the conditioned medium of porcine carotid arteries kept in culture after in vivo transduction, When carotid flow was measured with Doppler probe 5 days after surgery, cyclic flow variations (CFVs) developed in 7 of 8 control pigs after constriction of the injured carotid artery by 40%, and all control-treated arteries occluded after 70% constriction. In contrast, CFVs were observed in only 1 of 8 Ad-TFPI-treated pigs after 40% constriction, and only 3 of 8 occluded after constriction by 70% (P=0.0027 and P=0.007, respectively). None of the 5 TFPI-transduced arteries open after 70% constriction developed CFVs during an incremental epinephrine infusion. Conclusions-Compared with baseline, systemic hemostatic variables and platelet aggregation were unimpaired, suggesting that TFPI gene transfer can prevent arterial thrombosis in the presence of severe shear stress and without detectable hemostatic impairment.

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Documento generato il 02/04/20 alle ore 21:29:43