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Titolo:
Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays
Autore:
Steele, VE; Kelloff, GJ; Balentine, D; Boone, CW; Mehta, R; Bagheri, D; Sigman, CC; Zhu, SY; Sharma, S;
Indirizzi:
NCI, Chemoprevent Branch, Div Canc Prevent, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 , Div Canc Prevent, NIH, Bethesda, MD 20892 USA Mantech Environm Technol Inc, Res Triangle Pk, NC 27709 USA Mantech Environm Technol Inc Res Triangle Pk NC USA 27709 k, NC 27709 USA Univ Illinois, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612Univ Illinois, Chicago, IL 60612 USA CCS Associates, Mt View, CA 94043 USA CCS Associates Mt View CA USA 94043CCS Associates, Mt View, CA 94043 USA Thomas J Lipton Co, Englewood Cliffs, NJ 07632 USA Thomas J Lipton Co Englewood Cliffs NJ USA 07632 ood Cliffs, NJ 07632 USA
Titolo Testata:
CARCINOGENESIS
fascicolo: 1, volume: 21, anno: 2000,
pagine: 63 - 67
SICI:
0143-3334(200001)21:1<63:CCMOGT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEAL EPITHELIAL-CELLS; PHASE-II ENZYMES; (-)-EPIGALLOCATECHIN GALLATE; LIPID-PEROXIDATION; TUMOR INITIATION; CANCER CHEMOPREVENTION; N-NITROSODIETHYLAMINE; CAMELLIA-SINENSIS; MOUSE SKIN; A/J MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Steele, VE NCI, Chemoprevent Branch, Div Canc Prevent, NIH, EPN Room 201,MSC 7322,9000 Rockville Pike, Bethesda, MD 20892 USA NCI EPN Room 201,MSC 7322,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
V.E. Steele et al., "Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays", CARCINOGENE, 21(1), 2000, pp. 63-67

Abstract

Black tea extracts (hot aqueous, polyphenols and theaflavins) and green tea extracts (hot aqueous, polyphenols, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate) were tested in nine standardized cell culture assays for comparative cancer chemopreventive properties. Most black and green tea extracts strongly inhibited neoplastic transformation in mouse mammary organ cultures, rat tracheal epithelial cells and human lung tumor epithelial cells. Nearly all tea fractions strongly inhibited benzo[a]pyrene adduct formation with human DNA. Induction of phase II enzymes, glutathione-S-transferase and quinone reductase, were enhanced by nearly all tea fractions, while glutathione was induced by only a few fractions. Ornithine decarboxylase activity was inhibited by nearly all the green tea fractions, but none of the black tea fractions. 12-O-tetradecanoylphorbol-13-acetate-induced free radicals were inhibited by most tea fractions, These results provide strong evidence of both anti-mutagenic, anti-proliferative and anti-neoplastic activities for both black and green tea extracts. Such anticancer mechanisms may well be responsible for the cancer preventive efficacies seen in both experimental and human studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:14:45