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Titolo:
Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine
Autore:
Kitayama, W; Denda, A; Yoshida, J; Sasaki, Y; Takahama, M; Murakawa, K; Tsujiuchi, T; Tsutsumi, M; Konishi, Y;
Indirizzi:
Nara Med Univ, Ctr Canc, Dept Oncol Pathol, Nara 6348521, Japan Nara Med Univ Nara Japan 6348521 Dept Oncol Pathol, Nara 6348521, Japan Nara Med Univ, Dept Internal Med 2, Nara 6348521, Japan Nara Med Univ Nara Japan 6348521 ept Internal Med 2, Nara 6348521, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 148, anno: 2000,
pagine: 145 - 152
SICI:
0304-3835(20000201)148:2<145:IEOCPI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN G/H SYNTHASE-1; HUMAN COLON-CANCER; A/J MICE; EPITHELIAL-CELLS; TUMORIGENESIS; INHIBITION; PULMONARY; ACID; LOCALIZATION; SUPPRESSION;
Keywords:
cyclooxygenase-2; lung tumors; N-nitrosobis(2-hydroxypropyl)amine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Denda, A Nara Med Univ, Ctr Canc, Dept Oncol Pathol, 840 Shijocho, Nara 6348521, Japan Nara Med Univ 840 Shijocho Nara Japan 6348521 ara 6348521, Japan
Citazione:
W. Kitayama et al., "Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine", CANCER LETT, 148(2), 2000, pp. 145-152

Abstract

Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically. The majority of alveolar/bronchiolar adenomas (ADs) and all adenocarcinomas (ADCs) examined, stained positive or strongly positive for COX-2, in contrast, only a minority of alveolar/bronchiolarhyperplasias demonstrated immunoreactivity and half of the squamous cell carcinomas examined, were only weakly positive. Western blotting analysis also revealed expression of COX-2 protein in the resected ADs and ADCs. Theseresults clearly indicate up-regulated expression of COX-2 in lung neoplastic lesions, particularly ADs and ADCs, induced by BHP in rats. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:48:49