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Titolo:
Malignant tumours and psoriasis: climatotherapy at the Dead Sea
Autore:
Frentz, G; Olsen, JH; Avrach, WW;
Indirizzi:
Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark Danish Canc Soc Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Copenhagen Municipal Hosp, Inst Prevent Med, DK-1399 Copenhagen, Denmark Copenhagen Municipal Hosp Copenhagen Denmark DK-1399 Copenhagen, Denmark Panopticon Dermatol Ctr, DK-1570 Copenhagen, Denmark Panopticon Dermatol Ctr Copenhagen Denmark DK-1570 0 Copenhagen, Denmark
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 6, volume: 141, anno: 1999,
pagine: 1088 - 1091
SICI:
0007-0963(199912)141:6<1088:MTAPCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVB;
Keywords:
climatotherapy; cohort study; Dead Sea; non-melanoma skin cancer; psoriasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Olsen, JH Danish Canc Soc, Inst Canc Epidemiol, Strandboulevarden 49, DK-2100 Copenhagen, Denmark Danish Canc Soc Strandboulevarden 49 Copenhagen Denmark DK-2100
Citazione:
G. Frentz et al., "Malignant tumours and psoriasis: climatotherapy at the Dead Sea", BR J DERM, 141(6), 1999, pp. 1088-1091

Abstract

In this retrospective, nation-wide cohort study, the risk of cancer was assessed for 1738 Danish patients with psoriasis subjected to climatotherapy at the Dead Sea during 1972-93, by linkage to the Danish Cancer Registry. The overall risk of cancer in patients treated at the Dead Sea (standardizedincidence ratio, SIR = 1.59) was higher than that expected in the general population, owing to an excess risk of non-melanoma skin cancer (NMSC) [SIR= 4.2 for basal cell carcinoma (BCC) and 10.7 for squamous cell carcinoma (SCC)]. In addition, the distribution of NMSC among body sites, age groups and sexes was unusual in those treated at the Dead Sea, favouring NMSC in young individuals and at multiple sites (SIR = 10.7 for BCC and 57.2 for SCC), multiple BCCs being particularly common among young women, Thus, people subjected to climatotherapy at the Dead Sea for psoriasis constitute a high-risk group for NMSC, SCC in particular, but not for malignant diseases in general, The study design precludes conclusions on whether climatotherapy plays a specific part in skin carcinogenesis which is different from other sources of ultraviolet (UV) radiation, as climatotherapy is inevitably confounded by excess UV exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:40:51