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Titolo:
The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells
Autore:
Colucci, F; Di Santo, JP;
Indirizzi:
Hop Necker Enfants Malad, INSERM U429, Inst Natl Sante & Rech Med, Paris, France Hop Necker Enfants Malad Paris France l Sante & Rech Med, Paris, France
Titolo Testata:
BLOOD
fascicolo: 3, volume: 95, anno: 2000,
pagine: 984 - 991
SICI:
0006-4971(20000201)95:3<984:TRTKCP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-2 RECEPTOR; IL-2 RECEPTOR; GAMMA CHAIN; FLT3 LIGAND; BETA-CHAIN; IN-VIVO; MICE; STEM; PROGENITOR; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP Inst Pasteur, Lab Cytokines & Lymphoid Dev, 25 Rue Dr Roux, F-75015 Paris,France Inst Pasteur 25 Rue Dr Roux Paris France F-75015 aris,France
Citazione:
F. Colucci e J.P. Di Santo, "The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells", BLOOD, 95(3), 2000, pp. 984-991

Abstract

Fetal liver kinase ligands (flk2L/flt3L) and stem cell factor (SCF) have been shown to promote natural killer (NK) cell differentiation from hematopoietic stem cell (HSC) precursors in vitro. However, the contribution of signaling through the receptors for these growth factors for in vivo NK cell development remains ill-defined. We have analyzed the role of the SCF receptor c-kit in NK cell differentiation by reconstituting NK-deficient mice with fetal liver (FL) HSCs of c-kit(-/-) (W/W) mice. Although c-kit(-/-)NK cells were generated in W/W chimeras, they were reduced in number, contained alower percentage of CD45R (B220)(+) cells, and were poorly cytolytic, In vitro experiments showed that generation of NK cells from FL precursors was reduced in the absence of c-kit signaling and that SCF promoted the survival of peripheral c-kit(+) NK cells. We conclude that c-kit/SCF interactions in vivo are dispensable for the commitment of HSC to the NK lineage, but they provide essential signals for generating normal numbers of fully mature NK cells. (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:47:14