Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by [I-123]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography
Autore:
Neumeister, A; Pirker, W; Willeit, M; Praschak-Rieder, N; Asenbaum, S; Brucke, T; Kasper, S;
Indirizzi:
Univ Vienna, Dept Gen Psychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Gen Psychiat, A-1090 Vienna, Austria Univ Vienna, Dept Neurol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Neurol, A-1090 Vienna, Austria
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 158 - 160
SICI:
0006-3223(20000115)47:2<158:SVOAOS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CIT BINDING; TRYPTOPHAN DEPLETION; AFFECTIVE-DISORDER; HUMAN BRAIN; DOPAMINE;
Keywords:
serotonin; serotonin transporter; seasonal variation; brain imaging; single photon emission computed tomography; beta-CIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Neumeister, A Univ Vienna, Dept Gen Psychiat, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
A. Neumeister et al., "Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by [I-123]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography", BIOL PSYCHI, 47(2), 2000, pp. 158-160

Abstract

Background: Previous studies have indicated annual variations in central and peripheral serotonergic activity. In the present study we studied five women in summer and six women in winter and evaluated possible differences in availability of brain serotonin transporters between summer and winter. Methods: We employed the single photon emission computed tomography ligand[I-123]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([I-123]beta-CIT)to visualize binding to the serotonin transporter site in the human thalamus/ hypothalamus midbrain area in vivo. Brain imaging studies were performed in one group between May and August and in the other between November andDecember. Results: We found significant differences in displaceable [123I]beta-CIT binding in the region corresponding to thalamus/hypothalamus between the summer group and the Winter group (1.9 +/- 0.3 vs. 1.4 +/- 0.2, respectively; p < .01). Conclusions: The results of the present study suggest reduced brain serotonin transporter availability in winter. This finding further substantiates evidence of seasonal variations in brain serotonergic function. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:15:57