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Titolo:
Effects of acute tryptophan depletion on mood in bulimia nervosa
Autore:
Kaye, WH; Gendall, KA; Fernstrom, MH; Fernstrom, JD; McConaha, CW; Weltzin, TE;
Indirizzi:
Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 & Clin, Pittsburgh, PA 15213 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 151 - 157
SICI:
0006-3223(20000115)47:2<151:EOATDO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRAL AMINO-ACIDS; BRAIN-SEROTONIN CONTENT; PLASMA TRYPTOPHAN; EATING DISORDERS; HEALTHY-SUBJECTS; FEMALE VOLUNTEERS; RAPID DEPLETION; NORMAL MALES; FOOD-INTAKE; WOMEN;
Keywords:
bulimia nervosa; tryptophan depletion; serotonin; mood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kaye, WH Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 A 15213 USA
Citazione:
W.H. Kaye et al., "Effects of acute tryptophan depletion on mood in bulimia nervosa", BIOL PSYCHI, 47(2), 2000, pp. 151-157

Abstract

Background: The present study investigated the role of serotonin in the pathophysiology of bulimia nervosa (BN) by studying the affective and appetitive responses of women ill with BN to an acute tryptophan depletion (ATD) paradigm. Methods: Twenty-two women with BN and 16 healthy control women (CW) were studied on 2 separate days during the follicular stage of the menstrual cycle. Participants drank a control nth of essential amino acids (100 g + 4.6 gtryptophan) on one day and a tryptophan deficient (100 g - 4.6 g tryptophan) mixture (ATD) on the other in a double-blind fashion. Mood/appetite ratings and blood samples were taken at baseline and at intervals rip to 420 minutes. Participants were then presented with an array of foods and were allowed to binge and vomit if they desired. Results: CW and BN women had a similar and significant reduction in plasmatryptophan levels and the tryptophan: LNAA ratio after ATD, After ATD, theBN women had a significantly greater increase in peak (minus baseline) depression, mood lability, sadness and desire to binge compared to the CW. BN subjects and CW had similar-peak changes in mood after rite control amino acid mixture, BN subjects and CW consumed similar amounts of food after the two amino acid treatments. Conclusions: Women with BN seem more vulnerable to the mood lowering effects of ATD, suggesting they have altered modulation of central 5-HT neuronalsystems. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:23:27