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Titolo:
Dissociation of ketamine effects on rule acquisition and rule implementation: Possible relevance to NMDA receptor contributions to executive cognitive functions
Autore:
Krystal, JH; Bennett, A; Abi-Saab, D; Belger, A; Karper, LP; DSouza, DC; Lipschitz, D; Abi-Dargham, A; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat,Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 icoff Res Facil, New Haven, CT 06519 USA VA Connecticut Healthcare Syst, Psychiat Serv 116A, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA Serv 116A, W Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 137 - 143
SICI:
0006-3223(20000115)47:2<137:DOKEOR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARD SORTING TEST; DORSOLATERAL PREFRONTAL CORTEX; CEREBRAL BLOOD-FLOW; SCHIZOPHRENIC-PATIENTS; PHYSIOLOGIC DYSFUNCTION; BINDING-SITES; PERFORMANCE; PHENCYCLIDINE; ASPARTATE; ATTENTION;
Keywords:
Wisconsin Card Sorting Test; frontal cortex; ketamine; glutamate; learning and memory; schizophrenia; executive function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Krystal, JH Yale Univ, Sch Med, Dept Psychiat,Connecticut Mental Hlth Ctr,Abraham Ribicoff Res Facil, 34 Pk St, New Haven, CT 06519 USA Yale Univ 34Pk St New Haven CT USA 06519 Haven, CT 06519 USA
Citazione:
J.H. Krystal et al., "Dissociation of ketamine effects on rule acquisition and rule implementation: Possible relevance to NMDA receptor contributions to executive cognitive functions", BIOL PSYCHI, 47(2), 2000, pp. 137-143

Abstract

Background: The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components ofWCST performance, These aspects of WCST performance figure more prominently in the initial completion of this task than in subsequent task repetitions in healthy populations. Methods: In the first study, healthy subjects (n = 15) completed the WCST on Two occasions separated by I week. In the second study, healthy subjects(n = 22) completed two test days spaced by approximately I week, during which, they completed the WCST and other assessments after administration of the NMDA antagonist ketamine (intravenous bolus 0.26 mg/kg followed by infusion of 0.65 mg/kg/hour) or matched placebo. Results: In the first study, subjects reduced the number of total and perseverative errors with a single repetition of the WCST In the second study, ketamine significantly increased the number of total errors and the number and percent of perseverative errors on the first, but not the second rest day. Similarly, it reduced the number of category criteria met on the first,but not second test day. Ketamine also increased distractibility, impairedrecall, produced psychosis, altered perception, and had effects resemblingthe negative symptoms of schizophrenia. However, only WCST performance showed order dependency. Conclusions: This order dependency further implicates NMDA receptors in executive cognitive functions associated with the frontal cortex.

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Documento generato il 20/01/20 alle ore 22:22:33