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Titolo:
SPECT [I-123]Iomazenil measurement of the benzodiazepine receptor in panicdisorder
Autore:
Bremner, JD; Innis, RB; White, T; Fujita, M; Silbersweig, D; Goddard, AW; Staib, L; Stern, E; Cappiello, A; Woods, S; Baldwin, R; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA VA Connecticut Healthcare Syst, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA care Syst, W Haven, CT USA Natl Ctr PTSD W Haven, W Haven, CT USA Natl Ctr PTSD W Haven W Haven CT USA l Ctr PTSD W Haven, W Haven, CT USA Cornell Univ, Sch Med, Dept Psychiat, New York, NY 10021 USA Cornell UnivNew York NY USA 10021 Dept Psychiat, New York, NY 10021 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 96 - 106
SICI:
0006-3223(20000115)47:2<96:S[MOTB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC-STRESS-DISORDER; CEREBRAL BLOOD-FLOW; EPISODIC MEMORY; IOMAZENIL-SPECT; HIPPOCAMPAL VOLUME; I-123 IOMAZENIL; SWIM STRESS; HUMAN BRAIN; BINDING;
Keywords:
panic disorder; SPECT; neuroimaging; benzodiazepines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD Yale Psychiat Inst, Yale Stn, POB 208038, New Haven, CT 06520 USA Yale Psychiat Inst POB 208038 New Haven CT USA 06520 06520 USA
Citazione:
J.D. Bremner et al., "SPECT [I-123]Iomazenil measurement of the benzodiazepine receptor in panicdisorder", BIOL PSYCHI, 47(2), 2000, pp. 96-106

Abstract

Background: Alterations in benzodiazepine receptor function have long beenhypothesized to play a role in anxiety. Animal models of anxiety involvingexposure to chronic stress have shown a specific decrease in benzodiazepine receptor binding in frontal cortex and hippocampus, The purpose of this study was to examine benzodiazepine receptor binding patients with panic disorder and comparison subjects. Methods: A quantitative measure related to benzodiazepine receptor binding(Distribution Volume (DV)) was obtained with single photon emission computed tomography (SPECT) imaging of [I-123]iomazenil and measurement of radioligand concentration in plasma in patients with panic disorder and healthy controls. DV image data were analysed using statistical parametric mapping (spm96). Results: A decrease in measures benzodiazepine receptor binding (DV) was found in left hippocampus and precuneus in panic disorder patients relative to controls. Panic disorder patients who had a panic attack compared to patients who did not have a panic attack at the time of the scan had a decrease in benzodiazepine receptor binding in prefrontal cortex. Conclusions: Findings of a decrease in left hippocampal and precuneus benzodiazepine receptor binding may be related to alterations in benzodiazepinereceptor binding, or other factors including changes in GABAergic transmission or possible endogenous benzodiazepine compounds. Benzodiazepine receptor function in prefrontal cortex appears to be involved in changes in state-related panic anxiety. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 20/01/20 alle ore 16:01:47