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Titolo:
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
Autore:
Ricquier, D; Bouillaud, F;
Indirizzi:
CNRS, Ctr Rech Endocrinol Mol & Dev, Unit 9078, F-92190 Meudon, France CNRS Meudon France F-92190 Mol & Dev, Unit 9078, F-92190 Meudon, France
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 345, anno: 2000,
parte:, 2
pagine: 161 - 179
SICI:
0264-6021(20000115)345:<161:TUPHUU>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN-ADIPOSE-TISSUE; MESSENGER-RNA EXPRESSION; FREE FATTY-ACIDS; MITOCHONDRIAL PROTON LEAK; ACTIVATED RECEPTOR-GAMMA; JUVENILE-ONSET OBESITY; TUMOR-NECROSIS-FACTOR; RETINOID-X-RECEPTOR; CIS-ACTING ELEMENTS; LOW-CALORIE DIET;
Keywords:
carrier; energy; mitochondria; proton; thermogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
268
Recensione:
Indirizzi per estratti:
Indirizzo: Ricquier, D CNRS, Ctr Rech Endocrinol Mol & Dev, Unit 9078, 9 Rue Jules Hetzel, F-92190 Meudon, France CNRS 9 Rue Jules Hetzel Meudon France F-92190 Meudon, France
Citazione:
D. Ricquier e F. Bouillaud, "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP", BIOCHEM J, 345, 2000, pp. 161-179

Abstract

Animal and plant uncoupling protein (UCP) homologues form a subfamily of mitochondrial carriers that are evolutionarily related and possibly derived from a proton/anion transporter ancestor. The brown adipose tissue (BAT) UCP1 has a marked and strongly regulated uncoupling activity, essential to the maintenance of body temperature in small mammals. UCP homologues identified in plants are induced in a cold environment and may be involved in resistance to chilling. The biochemical activities and biological functions of the recently identified mammalian UCP2 and UCP3 are not well known. However,recent data support a role for these UCPs in State 4 respiration, respiration uncoupling and proton leaks in mitochondria. Moreover, genetic studies suggest that UCP2 and UCP3 play a part in energy expenditure in humans. TheUCPs may also be involved in adaptation of cellular metabolism to an excessive supply of substrates in order to regulate the ATP level, the NAD(+)/NADH ratio and various metabolic pathways, and to contain superoxide production. A major goal will be the analysis of mice that either lack the UCP2 or UCP3 gene or overexpress these genes. Other aims will be to investigate thepossible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:04:23