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Titolo:
Characterization of P8 and J8/7 elements in the conserved core of the Tetrahymena group I intron ribozyme
Autore:
Ikawa, Y; Shiraishi, H; Inoue, T;
Indirizzi:
Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Grad Sch Biostudies, Kyoto 6068502, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 267, anno: 2000,
pagine: 85 - 90
SICI:
0006-291X(20000107)267:1<85:COPAJE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE SEQUENCE-ANALYSIS; CATALYTIC CORE; BINDING-SITE; ACTIVE-SITE; 2 DOMAINS; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan Kyoto UnivKyoto Japan 6068502 Biostudies, Kyoto 6068502, Japan
Citazione:
Y. Ikawa et al., "Characterization of P8 and J8/7 elements in the conserved core of the Tetrahymena group I intron ribozyme", BIOC BIOP R, 267(1), 2000, pp. 85-90

Abstract

The universally conserved core region in the group I intron ribozymes is responsible for its catalytic activity, The structural elements in this region have been known to organize the active site of this class of ribozymes. However, it has been unclear whether all elements are requisite or some elements are dispensable for conducting the catalysis. To investigate the necessity of these elements in the catalysis, we prepared and examined a seriesof mutants having a nick or deletion in those elements. In this report, weshow that two elements, p8 and 5' portion of J8/7, are non-essential for activity. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:50:17