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Titolo:
Vaccinating chickens against avian influenza with fowlpox recombinants expressing the H7 haemagglutinin
Autore:
Boyle, DB; Selleck, P; Heine, HG;
Indirizzi:
CSIRO, Div Anim Hlth, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia CSIRO Geelong Vic Australia 3220 m Hlth Lab, Geelong, Vic 3220, Australia
Titolo Testata:
AUSTRALIAN VETERINARY JOURNAL
fascicolo: 1, volume: 78, anno: 2000,
pagine: 44 - 48
SICI:
0005-0423(200001)78:1<44:VCAAIW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS RECOMBINANT; A VIRUS; PROTECTION; DISEASE; RESPONSES; VICTORIA; IMMUNITY; H5N2;
Keywords:
chicken; avian influenza; fowl plague; fowlpox recombinants; vaccines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Boyle, DB CSIRO, Div Anim Hlth, Australian Anim Hlth Lab, Private Bag 24,5Portarlington Rd, Geelong, Vic 3220, Australia CSIRO Private Bag 24,5 Portarlington Rd Geelong Vic Australia 3220
Citazione:
D.B. Boyle et al., "Vaccinating chickens against avian influenza with fowlpox recombinants expressing the H7 haemagglutinin", AUST VET J, 78(1), 2000, pp. 44-48

Abstract

Objective To evaluate the vaccine efficacy of a fowlpox virus recombinant expressing the H7 haemagglutinin of avian influenza virus in poultryProcedure Specific-pathogen-free poultry were vaccinated with fowlpox recombinants expressing H7 or H1 haemagglutinins of influenza virus. Chickens were vaccinated at 2 or 7 days of age and challenged with virulent Australian avian influenza virus at 10 and 21 days later, respectively. Morbidity and mortality, body weight change and the development of immune responses to influenza haemagglutinin and nucleoprotein were recorded. Results Vaccination of poultry with fowlpox 1-17 avian influenza virus recombinants induced protective immune responses. All chickens vaccinated at 7days of age and clinical 21 days later were protected from death. Few clinical signs of infection developed. In contrast, unvaccinated or chickens vaccinated with a non-recombinant fowlpox or a fowlpox expressing the H1 haemagglutinin of human influenza were highly susceptible to avian influenza. All those chickens died within 72 h of challenge. In younger chickens, vaccinated at 2 days of age and challenged 10 days later the protection was lower with 80% of chickens protected from death. Chickens surviving vaccinationand challenge had high antibody responses to haemagglutinin and primary antibody responses to nucleoprotein suggesting that although vaccination protected substantially against disease it failed to completely prevent replication of the challenge avian influenza virus. Conclusion Vaccination of chickens with fowlpox virus expressing the avianinfluenza H7 haemagglutinin provided good protection against experimental challenge with virulent avian influenza of H7 type. Although eradication will remain the method of first choice for control of avian influenza, in thecircumstances of a continuing and widespread outbreak the availability of vaccines based upon fowlpox recombinants provides an additional method for disease control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 05:01:22