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Titolo:
Effect of quercetin, caffeic acid and caffeic acid phenylethyl ester, solubilized in non-ionic surfactants, on histamine release in vivo and in vitro
Autore:
Scheller, S; Dworniczak, S; Pogorzelska, T; Rajca, MK; Shani, J;
Indirizzi:
Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmacol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Silesian Acad Med, Dept Microbiol & Immunol, Zabrze Rokitnica, Poland Silesian Acad Med Zabrze Rokitnica Poland nol, Zabrze Rokitnica, Poland Silesian Acad Med, Dept Physiol, Zabrze Rokitnica, Poland Silesian Acad Med Zabrze Rokitnica Poland iol, Zabrze Rokitnica, Poland
Titolo Testata:
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
fascicolo: 1, volume: 50, anno: 2000,
pagine: 72 - 76
SICI:
0004-4172(200001)50:1<72:EOQCAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL MAST-CELLS; CREMOPHOR-EL; ANAPHYLACTOID REACTIONS; PROPOLIS; DERIVATIVES; RESISTANCE; DOGS;
Keywords:
caffeic acid; caffeic acid phenylethyl ester; Cremophor EL; Cremophor RH40; histamine release; mast cells; quercetin; Solutol HS15; surfactants; Tween 80;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Shani, J Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmacol, POB 12065, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem POB 12065 Jerusalem Israel IL-91120 Israel
Citazione:
S. Scheller et al., "Effect of quercetin, caffeic acid and caffeic acid phenylethyl ester, solubilized in non-ionic surfactants, on histamine release in vivo and in vitro", ARZNEI-FOR, 50(1), 2000, pp. 72-76

Abstract

A practical hindrance in using many therapeutic agents is their limited solubility in aqueous matrixes. This is usually overcome by incorporating theactive compounds in a matrix, with the aid of a non-ionic surfactant. Three water-insoluble natural polyphenols with inherent biological activity, quercetin (CAS 117-39-5), caffeic acid and caffeic acid phenylethyl ester, were solubilized in water, with the aid of Tween(R) 80 (an esterified and polyethoxylated derivative of sorbitan). Solutol(R) HS15 (a polyethoxylated derivative of 12-hydroxy-stearic acid), Cremophor(R) RH40 (a ricinoleic acid derivative) or Cremophor(R) EL and the effect of the solubilized polyphenols on histamine release was studied in vitro (mast cells) and in vivo in therat. In vivo Cremophor EL alone increased, and Tween 80 decreased histamine plasma levels. All four groups injected with solubilized quercetin exhibited adecrease in their plasma histamine levels. Caffeic acid solubilized in Cremophor RH40 decreased histamine levels, too. In vitro Tween 80 increased histamine release in a dose-dependent mode. Quercetin in vitro inhibited histamine release in all solubilizers used. It is concluded that the ability of the studied polyphenols to release histamine is not only depending on the condition of the storage vesicles in the mast cells, but also on the surfactant used to solubilize them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:44:51