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Titolo:
QUANTIFICATION OF DOPAMINE D1 AND D2 RECEPTOR MESSENGER-RNA LEVELS ASSOCIATED WITH THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION IN AMPHETAMINE TREATED RATS
Autore:
RICHTAND NM; KELSOE JR; KUCZENSKI R; SEGAL DS;
Indirizzi:
UNIV CINCINNATI,COLL MED,DEPT PSYCHIAT,231 BETHESDA AVE,ML 559 CINCINNATI OH 45267 SAN DIEGO VET AFFAIRS MED CTR,DEPT PSYCHIAT LA JOLLA CA 92161 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT LA JOLLA CA 92093
Titolo Testata:
Neurochemistry international
fascicolo: 1, volume: 31, anno: 1997,
pagine: 131 - 137
SICI:
0197-0186(1997)31:1<131:QODDAD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR ACTIVITY; VENTRAL TEGMENTAL AREA; MESSENGER-RNA; NUCLEUS-ACCUMBENS; COCAINE; BRAIN; AUGMENTATION; INJECTION; MORPHINE; SINGLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N.M. Richtand et al., "QUANTIFICATION OF DOPAMINE D1 AND D2 RECEPTOR MESSENGER-RNA LEVELS ASSOCIATED WITH THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION IN AMPHETAMINE TREATED RATS", Neurochemistry international, 31(1), 1997, pp. 131-137

Abstract

We hypothesized that changes in expression of dopamine (DA) D1 and D2receptor genes in caudate/putamen (CP) would correlate with the development of behavioral changes in amphetamine treated rats. In order to test this hypothesis, we measured DA D1 and D2 receptor mRNA in CP, aswell as locomotor behavior, in individual rats following amphetamine treatment. D1 and D2 mRNA levels were similar in caudate/putamen of rats treated with acute amphetamine, chronic amphetamine or saline injection. We found no correlation between D1 or D2 mRNA levels in caudate/putamen and the behavioral response to either acute or chronic amphetamine. These results suggest that behavioral sensitization to amphetamine is not mediated through transcriptional regulation of D1 or D2 mRNAlevels in caudate/putamen. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:02:12