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Titolo:
Glutathione-S-transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase
Autore:
Villafania, A; Anwar, K; Amar, S; Chie, L; Way, D; Chung, DL; Adler, V; Ronai, Z; Brandt-Rauf, PW; Yamaizumii, Z; Kung, HF; Pincus, MR;
Indirizzi:
VA Med Ctr, Dept Pathol & Lab Med, Brooklyn, NY 11209 USA VA Med Ctr Brooklyn NY USA 11209 Pathol & Lab Med, Brooklyn, NY 11209 USA Long Isl Univ, Dept Chem, Brooklyn, NY USA Long Isl Univ Brooklyn NY USALong Isl Univ, Dept Chem, Brooklyn, NY USA Long Isl Univ, Dept Biol, Brooklyn, NY USA Long Isl Univ Brooklyn NY USALong Isl Univ, Dept Biol, Brooklyn, NY USA Mt Sinai Med Ctr, Ruttenberg Canc Ctr, New York, NY 10029 USA Mt Sinai MedCtr New York NY USA 10029 g Canc Ctr, New York, NY 10029 USA Columbia Univ, Coll Phys & Surg, Div Environm Sci, New York, NY USA Columbia Univ New York NY USA & Surg, Div Environm Sci, New York, NY USA Natl Canc Inst, Tokyo, Japan Natl Canc Inst Tokyo JapanNatl Canc Inst, Tokyo, Japan NCI, Lab Biochem Physiol, Frederick, MD 21701 USA NCI Frederick MD USA 21701 , Lab Biochem Physiol, Frederick, MD 21701 USA SUNY Hlth Sci Ctr, Dept Pathol, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 pt Pathol, Brooklyn, NY 11203 USA
Titolo Testata:
ANNALS OF CLINICAL AND LABORATORY SCIENCE
fascicolo: 1, volume: 30, anno: 2000,
pagine: 57 - 64
SICI:
0091-7370(200001)30:1<57:GAASIO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE; MONOCLONAL-ANTIBODIES; OOCYTE MATURATION; RAS-P21 PROTEIN; RAS GENES; P21(RAS); INSULIN;
Keywords:
glutathione-S-transferase; jun kinase; jun; ras-p21; oocyte maturation; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Pincus, MR VA Med Ctr, Dept Pathol & Lab Med, 800 Poly Pl, Brooklyn, NY 11209 USA VA Med Ctr 800 Poly Pl Brooklyn NY USA 11209 klyn, NY 11209 USA
Citazione:
A. Villafania et al., "Glutathione-S-transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase", ANN CLIN L, 30(1), 2000, pp. 57-64

Abstract

We have identified the intracellular detoxification enzyme, glutathione-S-transferase (GST), as a potent inhibitor of the activation of jun by its kinase, jun-N-terminal kinase (JNK), in vitro. All three major isozymes (alpha, mu, and pi) bind to JNK-jun complexes and inhibit activation of jun by JNK. We now find that GST inhibits JNK-induced oocyte maturation in vivo andstrongly inhibits oocyte maturation induced by oncogenic ras-p21 protein, but not by insulin-activated normal cellular p21 protein. These results correlate with the finding that oncogenic, but not insulin-activated normal, p21 induces high levels of activated JNK. GST also strongly blocks inductionof oocyte maturation by protein kinase C (PKC) which is a critical downstream target of oncogenic but not normal ras-p21. Thus, we have established anew function for GST as a potent physiological inhibitor of the ras-JNK-jun pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:34:47