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Titolo:
Influence of NH4Cl on polarized release of endogenous protein degradation products and on morphology in LLC-PK1 cells
Autore:
Wardelmann, E; Ling, H; Heim, I; Schlebusch, H; Heidland, A; Pfeifer, U;
Indirizzi:
Univ Bonn, Dept Pathol, D-53127 Bonn, Germany Univ Bonn Bonn Germany D-53127 Bonn, Dept Pathol, D-53127 Bonn, Germany Univ Wurzburg, Div Nephrol, Dept Internal Med, Wurzburg, Germany Univ Wurzburg Wurzburg Germany ol, Dept Internal Med, Wurzburg, Germany Univ Bonn, Div Clin Chem, Dept Gynecol & Obstet, D-5300 Bonn, Germany UnivBonn Bonn Germany D-5300 ept Gynecol & Obstet, D-5300 Bonn, Germany
Titolo Testata:
AMERICAN JOURNAL OF NEPHROLOGY
fascicolo: 1, volume: 20, anno: 2000,
pagine: 74 - 81
SICI:
0250-8095(200001/02)20:1<74:IONOPR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL TUBULE CELLS; RENAL HYPERTROPHY; METABOLISM; INDUCTION; AMMONIA; CYSTINOSIS; AUTOPHAGY; CULTURES; TURNOVER; GROWTH;
Keywords:
ammonium chloride; renal tubular cells; lysosomal endogenous protein degradation release of degradation products; renal hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Wardelmann, E Univ Bonn, Dept Pathol, Siegmund Freud Str 25, D-53127 Bonn,Germany Univ Bonn Siegmund Freud Str 25 Bonn Germany D-53127 ermany
Citazione:
E. Wardelmann et al., "Influence of NH4Cl on polarized release of endogenous protein degradation products and on morphology in LLC-PK1 cells", AM J NEPHR, 20(1), 2000, pp. 74-81

Abstract

Increased renal ammoniagenesis is thought to be a causative factor for renal hypertrophy which occurs in several disorders accompanied by metabolic acidosis, We studied the influence of ammonia on the polarized release of degradation products of endogenous proteins in LLC-PK1 cells, Release of acid-soluble radioactivity to the extracellular space decreased under the influence of NH4Cl with a remarkable transient reduction of basolateral release,Electron microscopically NH4Cl-treated cells showed numerous enlarged lysosomes suggesting an accumulation of incompletely degraded cytoplasmatic material in the lysosomal compartment, We conclude that split products of lysosomal degradation of endogenous proteins are preferentially transported to the extracellular space via the basolateral plasma membrane, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:57:54