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Titolo:
Clinical implications of antineutrophil cytoplasmic antibody test in lupusnephritis
Autore:
Chin, HJ; Ahn, C; Lim, CS; Chung, HK; Lee, JG; Song, YW; Lee, HS; Han, JS; Kim, S; Lee, JS;
Indirizzi:
Seoul Natl Univ Hosp, Div Nephrol, Coll Med, Congro Ku, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ Hosp, Div Rheumatol, Coll Med, Congro Ku, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ Hosp, Div Pathol, Coll Med, Congro Ku, Seoul 110744, SouthKorea Seoul Natl Univ Hosp Seoul South Korea 110744 , Seoul 110744, SouthKorea Seoul Natl Univ Hosp, Clin Res Ctr, Coll Med, Congro Ku, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea
Titolo Testata:
AMERICAN JOURNAL OF NEPHROLOGY
fascicolo: 1, volume: 20, anno: 2000,
pagine: 57 - 63
SICI:
0250-8095(200001/02)20:1<57:CIOACA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHEMATOSUS; AUTOANTIBODIES; MYELOPEROXIDASE; VASCULITIS; ANCA; IMMUNOFLUORESCENCE; SPECIFICITY; PREVALENCE; DISEASE;
Keywords:
lupus nephritis; antineutrophil cytoplasmic antibody antilactoferrin antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ahn, C Seoul Natl Univ Hosp, Div Nephrol, Coll Med, Congro Ku, 28 Yunkun Don, Seoul 110744, South Korea Seoul Natl Univ Hosp 28 Yunkun Don Seoul South Korea 110744 Korea
Citazione:
H.J. Chin et al., "Clinical implications of antineutrophil cytoplasmic antibody test in lupusnephritis", AM J NEPHR, 20(1), 2000, pp. 57-63

Abstract

To elucidate the prevalence and clinical implications of antineutrophil cytoplasmic antibody (ANCA) in lupus nephritis (LN), we examined ANCA by indirect immunofluorescence and by ELISA against antilactoferrin (anti-LF) and antimyeloperoxidase (anti-MPO) antibody. To discriminate perinuclear ANCA (pANCA) with antinuclear antibody (ANA), all the ANCA-positive sera were tested again after incubating patients' sera with single-stranded (SS) and double-stranded (ds) DNA. These results were compared with clinicopathologic manifestations and clinical courses of LN. ANCA was positive in 19 (37.3%) of 51 LN patients. Among these LN patients, 3 had cytoplasmic ANCA (cANCA) and 16 had pANCA, ANCA was not found in 8 SLE patients without nephritis and30 normal controls. The presence of ANCA, particularly pANCA, was associated with the presence of nephritis (18/51 cases vs. 0/8 cases, p < 0.05), especially with diffuse proliferative lupus nephritis, WHO class IV (17/18 cases vs. 21/31 cases, p < 0.05) as well as the presence of anti-dsDNA antibody (17/19 cases vs. 18/30 cases, p < 0.05). Patients with ANCA frequently had deterioration of renal function (3/16 vs. 0/26 cases). Anti-LF antibody was positive in 13 patients, Among those, 12 patients had nephritis, Five patients with anti-LF antibody did not have ANCA, but 7 had pANCA, and 1 hadcANCA. Patients with anti-LF antibody had lower initial creatinine levels than those without it [serum creatinine (mg/dl): 0.78 (0.6-1.0) vs. 1.43 (0.5-5.0), p < 0.05]. Anti-MPO antibody was positive in only 1 patient, suggesting that MPO is a rare antigen for ANCA in LN, Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 28/03/20 alle ore 14:16:57