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Titolo:
Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers
Autore:
Kawanishi, K; Doki, Y; Shiozaki, H; Yano, M; Inoue, M; Fukuchi, N; Utsunomiya, T; Watanabe, H; Monden, M;
Indirizzi:
Osaka Univ, Sch Med, Dept Surg 2, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Surg 2, Suita, Osaka 5650871, Japan Gunma Univ, Sch Med, Dept Orthoped Surg, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 oped Surg, Maebashi, Gumma 371, Japan
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 2, volume: 113, anno: 2000,
pagine: 266 - 274
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ESOPHAGEAL CANCER; ALPHA-CATENIN EXPRESSION; SQUAMOUS-CELL CARCINOMA; EPIDERMAL GROWTH-FACTOR; IMMUNOHISTOCHEMICAL EVALUATION; ADHESION MOLECULES; CONTACT REGULATION; COLORECTAL-CANCER; BLADDER-CARCINOMA; MEDIATED ADHESION;
Keywords:
E-cadherin; autocrine motility factor receptor; invasion; metastasis; gastric cancers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Doki, Y Osaka Univ, Sch Med, Dept Surg 2, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
K. Kawanishi et al., "Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers", AM J CLIN P, 113(2), 2000, pp. 266-274

Abstract

Loss of intercellular adhesion and increased cell motility synergisticallyfacilitate tumor cell invasion. We studied these factors in 90 patients with gastric cancers by using an immunohistochemical technique to detect strong or weak expression of E-cadherin (ECD) and autocrine motility factor receptor (AMFR). Normal gastric mucosa (control) reacted strongly for ECD and weakly for AMFR. In study cases, ECD was weak in 47 cases, and AMFR was strong in 39 cases. Weak ECD and strong AMFR expression were associated with tumor dedifferentiation. AMFR expression correlated positively with depth ofinvasion but not with lymph node metastasis. ECD expression correlated negatively with lymph node metastasis but not with depth of invasion. A stronginverse correlation was found between ECD and AMFR expression. Tumors withweak ECD and strong AMFR expression displayed a more aggressive phenotype than tumors with strong ECD and weak AMFR expression. The postoperative survival of patients with tumors with weak ECD and strong AMFR expression was significantly shorter than that of other groups. Since they are involved inthe pathway to development of tumors with a more aggressive phenotype, ECDand AMFR should be examined to evaluate the biologic potential of gastric cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:22:45