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Titolo:
Ciliostimulatory effects mediated by nitric oxide
Autore:
Runer, T; Lindberg, S;
Indirizzi:
Univ Lund Hosp, Dept Otorhinolaryngol Head & Neck Surg, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 ead & Neck Surg, S-22185 Lund, Sweden
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 7, volume: 119, anno: 1999,
pagine: 821 - 825
SICI:
0001-6489(1999)119:7<821:CEMBNO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY BEAT FREQUENCY; ARTERIAL SMOOTH-MUSCLE; MUCOCILIARY ACTIVITY; SUBSTANCE-P; ENDOTHELIAL-CELLS; OBLIGATORY ROLE; UPPER AIRWAYS; HUMAN NOSE; RELAXATION; MODULATION;
Keywords:
adenoid; dibutyryl cyclic adenosine monophosphate; dibutyryl cyclic guanosine monophosphate; endothelin-1; human; methacholine; mucociliary function; substance P; terbutaline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Runer, T Blekinge Hosp, Dept Otorhinolaryngol, SE-35185 Karlskrona, SwedenBlekinge Hosp Karlskrona Sweden SE-35185 185 Karlskrona, Sweden
Citazione:
T. Runer e S. Lindberg, "Ciliostimulatory effects mediated by nitric oxide", ACT OTO-LAR, 119(7), 1999, pp. 821-825

Abstract

Ciliostimulation induced by various transmitters has been suggested to be mediated by the release of nitric oxide (NO). Freshly obtained adenoid tissue explants were pre-treated with the nitric oxide synthase (NOS) inhibitorNc-nitro L-arginine (r-NNA), to determine whether the ciliostimulators terbutaline, methacholine, substance P, and endothelin-l require the release of NO to increase ciliary bear frequency (CBF) in vitro. The r-NNA pre-treatment affected the change in CBF induced by each of the ciliostimulators tested. To determine whether cyclic nucleotides also stimulate CBF by inducingthe release of NO, an extra series of experiments were performed with dibutyryl cAMP and dibutyryl cGMP, and r-NNA pre-treatment. In contrast to the experiments with the various ciliostimulators: both dibutyryl cAMP and dibutyryl cGMP exerted ciliostimulatory effects that could not be inhibited by r-NNA. The present findings suggest that NO acts as an intermediate messenger in the ciliated epithelium in response to various transmitters and mediators. On the other hand, pre-treatment with the NOS inhibitor r-NNA did notaffect ciliary response to the second messengers cAMP and cGMP. thus suggesting that NO dependent mechanisms do not constitute the sole pathway for the stimulation of ciliary function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 03:13:03