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Titolo:
X-ray structure analysis of substituted 5-(2,3-dihydro-7-benzofuryl)-1-methylpyrazolo[4,3-d]pyrimidin-7-one (Biagra)
Autore:
Voelter, W; Maichle-Mossmer, C; Khanfar, MA; El-Abadelah, MM; Sabri, SS;
Indirizzi:
Univ Tubingen, Inst Physiol Chem, Phys Biochem Abt, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 em Abt, D-72076 Tubingen, Germany Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany Univ TubingenTubingen Germany D-72076 n Chem, D-72076 Tubingen, Germany Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Jordan Amman JordanUniv Jordan, Fac Sci, Dept Chem, Amman, Jordan
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
fascicolo: 12, volume: 54, anno: 1999,
pagine: 1602 - 1605
SICI:
0932-0776(199912)54:12<1602:XSAOS5>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-5 CGMP PHOSPHODIESTERASE; CORPUS CAVERNOSUM; NITRIC-OXIDE; SILDENAFIL; INHIBITOR; NEUROTRANSMISSION; RELAXATION; ERECTION; MEDIATOR; RABBIT;
Keywords:
dihydrobezofuryl-pyrazolo[4,3-d]pyrimidin-7-one; X-ray data;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Voelter, W Univ Tubingen, Inst Physiol Chem, Phys Biochem Abt, Hoppe Seyler Str 4, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 4 Tubingen Germany D-72076 many
Citazione:
W. Voelter et al., "X-ray structure analysis of substituted 5-(2,3-dihydro-7-benzofuryl)-1-methylpyrazolo[4,3-d]pyrimidin-7-one (Biagra)", Z NATURFO B, 54(12), 1999, pp. 1602-1605

Abstract

X-ray crystal structure data for the title compound dihydrobenzofuryl-pyrazolo[4,3-d]pyrimidin-7-one (2) reveal that the two bicyclic heteroaryl systems are virtually coplanar along their joint C(5)-C(11) axis with an interplanar angle of 1.13 degrees, This planar conformation is held by an intramolecular hydrogen bond between the pyrimidinone N(6)-H and the O(17) lone pair of the dihydrobenzofuryl moiety. The spatial interatomic distance for O(17)-N(6), determined as 2.04 Angstrom favours this PI-bridge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:55:26