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Titolo:
EXPRESSION OF THE ALPHA-7 SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IN NORMAL AND MYASTHENIC HUMAN THYMUSES
Autore:
NAVANEETHAM D; PENN A; HOWARD J; CONTIFINE BM;
Indirizzi:
UNIV MINNESOTA,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN 55108 UNIV MINNESOTA,DEPT BIOCHEM ST PAUL MN 55108 UNIV MINNESOTA,DEPT PHARMACOL MINNEAPOLIS MN 55455 NINCDS,NIH,OFF DIRECTOR BETHESDA MD 20892 UNIV N CAROLINA,DEPT NEUROL CHAPEL HILL NC 27599
Titolo Testata:
Cellular and molecular biology
fascicolo: 3, volume: 43, anno: 1997,
pagine: 433 - 442
SICI:
0145-5680(1997)43:3<433:EOTASO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINE; MESSENGER-RNAS; PHARMACOLOGICAL PROPERTIES; INTRATHYMIC PATHOGENESIS; MOLECULAR-CLONING; RAT THYMUS; GRAVIS; MUSCLE; ANTIBODIES; PROTEIN;
Keywords:
ACETYLCHOLINE RECEPTOR; ALPHA-7 SUBUNIT; HUMAN THYMUS; MYASTHENIA GRAVIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
D. Navaneetham et al., "EXPRESSION OF THE ALPHA-7 SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IN NORMAL AND MYASTHENIC HUMAN THYMUSES", Cellular and molecular biology, 43(3), 1997, pp. 433-442

Abstract

The nicotinic acetylcholine receptor (AChR) is a transmembrane glycoprotein composed of five homologous subunits. Different isoforms of theAChR alpha subunit exist (alpha 1 to alpha 9). Of them, alpha 1 is expressed in muscle, alpha 2 to alpha 9 in neuronal cells. Muscle AChR is the target autoantigen in the autoimmune disease myasthenia gravis (MG). The thymus is implicated in MG pathogenesis, and the anti-AChR autoimmune response may start in this tissue, that expresses the muscle-type alpha 1 subunit as well as other muscle AChR subunits. The thymusalso expresses the ''neuronal'' alpha 3 and alpha 5 subunits. By using polymerase chain reaction and other molecular techniques, we demonstrate here expression of the AChR alpha 7 subunit transcript in thymuses from both myasthenic patients and normal subjects. The alpha 7 subunit can form homo-oligomeric functional AChR complexes that, like muscle AChR, bind alpha-bungarotoxin. The demonstration of expression of the alpha 7 subunit in the thymus suggests that alpha-bungarotoxin binding, functional AChRs of the neuronal type are normally present in the thymus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:23:48