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Titolo:
Activation of the mesocorticolimbic dopaminergic system by stimulation of muscarinic cholinergic receptors in the ventral tegmental area
Autore:
Gronier, B; Perry, KW; Rasmussen, K;
Indirizzi:
Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Corp CtrIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 147, anno: 2000,
pagine: 347 - 355
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUAL-PROBE MICRODIALYSIS; RAT-BRAIN; NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA; SCHIZOPHRENIC-PATIENTS; EXTRACELLULAR LEVELS; PREFRONTAL CORTEX; NEGATIVE SYMPTOMS; LESIONED RATS; PARS COMPACTA;
Keywords:
A10 region; muscarinic receptor; microdialysis; mesocorticolimbic dopaminergic system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Gronier, B Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis IN USA 46285 napolis, IN 46285 USA
Citazione:
B. Gronier et al., "Activation of the mesocorticolimbic dopaminergic system by stimulation of muscarinic cholinergic receptors in the ventral tegmental area", PSYCHOPHAR, 147(4), 2000, pp. 347-355

Abstract

Objective: To investigate the function of muscarinic receptors in the ventral tegmental area in vivo, the release of endogenous monoamines was simultaneously measured in the somatodendritic (ventral tegmental area) and terminal (frontal cortex and nucleus accumbens) regions of the mesocorticolimbicdopaminergic system in rats, using dual probe microdialysis. Methods: Ratswere implanted with dual microdialysis probes ipsilaterally into the ventral tegmental area (VTA) and nucleus accumbens (NAC) or frontal cortex (FC). Results: Intrategmental infusion of the muscarinic a,agonist oxotremorine M (OXO M, 0.1 and 1 mM) increased extracellular levels of dopamine and serotonin, but not noradrenaline, in the VTA to a maximum of 200% over baselinein both urethane-anaesthetized and unanaesthetized rats. In freely moving animals, this effect was accompanied by strong motor agitation. Both VTA dopamine and serotonin levels dropped to 60% or less of baseline when the perfusion medium was replaced by a calcium-free medium containing OXO M. In the NAC and FC, a similar increase in extracellular dopamine, but not serotonin and noradrenaline, was observed during OXO M infusion in the VTA. The removal of calcium during OXO M infusion in the VTA did not cause a decrease in NAC dopamine levels. Activation of serotonin and dopamine release by OXOM in the VTA and FC was dramatically reduced or prevented by the coinfusion of the muscarinic antagonist N-methylscopolamine (0.1 mM). Conclusion: These data demonstrate that VTA dopamine cells possess functional muscarinic receptors whose activation stimulates the release of dopamine in the VTA, NAC and FC. These results also suggest that muscarinic receptors may modulate the synaptic release of serotonin in the VTA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 06:23:23