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Titolo:
AUDITORY-EVOKED POTENTIALS IN YOUNG-PATIENTS WITH DOWN-SYNDROME - EVENT-RELATED POTENTIALS (P3) AND HISTAMINERGIC SYSTEM
Autore:
SEIDL R; HAUSER E; BERNERT G; MARX M; FREILINGER M; LUBEC G;
Indirizzi:
UNIV HOSP VIENNA,DEPT PEDIAT,WAHRINGERGURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV HOSP VIENNA,DEPT PEDIAT A-1090 VIENNA AUSTRIA
Titolo Testata:
Cognitive brain research
fascicolo: 4, volume: 5, anno: 1997,
pagine: 301 - 309
SICI:
0926-6410(1997)5:4<301:APIYWD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM RESPONSES; SYNDROME INDIVIDUALS; COGNITIVE NEUROSCIENCE; ALZHEIMERS-DISEASE; HEALTHY-VOLUNTEERS; CHILDREN; DEMENTIA; DISORDER; MEMORY; HIPPOCAMPUS;
Keywords:
DOWN SYNDROME; CHILD; BRAIN-STEM AUDITORY EVOKED POTENTIAL; AUDITORY EVENT-RELATED POTENTIAL; P3; PHENIRAMINE; HISTAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
R. Seidl et al., "AUDITORY-EVOKED POTENTIALS IN YOUNG-PATIENTS WITH DOWN-SYNDROME - EVENT-RELATED POTENTIALS (P3) AND HISTAMINERGIC SYSTEM", Cognitive brain research, 5(4), 1997, pp. 301-309

Abstract

Subjects with Down syndrome exhibit various types of cognitive impairment. Besides abnormalities in a number of neurotransmitter systems (e.g. cholinergic), histaminergic deficits have recently been identified. Brainstem auditory evoked potentials (BAEPs) and auditory event-related potentials (ERPs), were recorded from 10 children (aged 11-20 years) with Down syndrome and from 10 age- and sex-matched healthy controlsubjects. In Down subjects, BAEPs revealed shortened latencies for peaks III and V with shortened interpeak latencies I-III and I-V. ERPs showed a delay of components N1, P2, N2 and P3. In addition, subjects with Down syndrome failed to show P3 amplitude reduction during repeated stimulation. To evaluate the cognitive effects of histaminergic dysfunction, ERPs were recorded from 12 healthy adults (aged 20-28 years) before and after antihistaminergic intervention (pheniramine) comparedto placebo. Whereas components N1, P2, N2 remained unchanged after Hi-receptor antagonism, P3 latency increased and P3 amplitude showed no habituation in response to repeated stimulation. The results suggest that the characteristic neurofunctional abnormalities present in children with Down syndrome must be the consequence of a combination of structural and neurochemical aberrations. The second finding was that antihistaminergic treatment affects information processing tested by ERPs similar to that seen with anticholinergic treatment.

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Documento generato il 19/01/20 alle ore 20:18:18