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Titolo:
Behavioral effects of GABA(A) receptor stimulation and GABA-transporter inhibition
Autore:
Schmitt, U; Luddens, H; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 , Dept Psychiat, D-55101 Mainz, Germany
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 65, anno: 2000,
pagine: 351 - 356
SICI:
0091-3057(200002)65:2<351:BEOGRS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; GAMMA-AMINOBUTYRIC-ACID; OPEN-FIELD; ANXIOLYTIC BENZODIAZEPINES; RAT BEHAVIOR; TEST BATTERY; ANXIETY; PHARMACOLOGY; TIAGABINE; DIAZEPAM;
Keywords:
rat behavior; GABA transporter; benzodiazepines; anxiety; tiagabine; zolpidem; diazepam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55101 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55101 ermany
Citazione:
U. Schmitt et al., "Behavioral effects of GABA(A) receptor stimulation and GABA-transporter inhibition", PHARM BIO B, 65(2), 2000, pp. 351-356

Abstract

The present analysis addressed behavioral changes after treatment with 4.5mg/kg or 18.5 mg/kg of the GABA-uptake inhibitor tiagabine combined with either the benzodiazepine diazepam (1.5 mg/kg) or the imidazopyridine zolpidem (0.05 mg/kg), the latter two acting differentially on GABA(A) receptor subtypes. The study included 97 male PVG/OIaHsd rats. A standard open field,an enriched open field, and an elevated plus-maze was used to study rat behavior. Treatment with the low dose of tiagabine alone induced no specific behavioral effects, whereas the high dose had an anxiolytic-like potential. Furthermore, diazepam but not zolpidem displayed anxiolytic-like effects. Combination of each benzodiazepine receptor agonist with tiagabine at the low dose decreased explorative activity. Diazepam plus the high dose of tiagabine increased the activity in the open-field test. Zolpidem together with18.5 mg/kg tiagabine had an angiogenic-like effect compared to pure tiagabine treatment. These results provide evidence for a pharmacodynamic interaction between the GABA-uptake inhibitor tiagabine and diazepam or zolpidem. The interaction might be relevant in the clinic when combining the anticonvulsant tiagabine and a benzodiazepine receptor agonist. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:32:46